Coumermycin A1
Coumermycin A1 is an aminocoumarin.[1][2] Its main target is the ATPase site of the DNA Gyrase GyrB subunit .[3]
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Other names | Coumamycin |
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ECHA InfoCard | 100.164.703 ![]() |
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Formula | C55H59N5O20 |
Molar mass | 1110.092 g·mol−1 |
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See also
References
- Heide L (2009). "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology Advances. 27 (6): 1006–1014. doi:10.1016/j.biotechadv.2009.05.017. PMID 19463934.
- Heide L, Gust B, Anderle C, Li SM (2008). "Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics". Current Topics in Medicinal Chemistry. 8 (8): 667–79. doi:10.2174/156802608784221505. PMID 18473891.
- Vanden Broeck A, McEwen AG, Chebaro Y, Potier N, Lamour V (April 2019). "Structural Basis for DNA Gyrase Interaction with Coumermycin A1". Journal of Medicinal Chemistry. 62 (8): 4225–4231. doi:10.1021/acs.jmedchem.8b01928. PMID 30920824.
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