Urofollitropin

Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified[1] to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.[2] It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.[2]

Urofollitropin
Clinical data
Trade namesBravelle, Fertinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • US: X (Contraindicated)
    Routes of
    administration    		Subcutaneous, intramuscular
    ATC code
    Legal status
    Legal status
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    • none
    UNII
    KEGG
    ChEMBL
    ECHA InfoCard100.212.030
    Chemical and physical data
    FormulaC975H1513N267O304S26
    Molar mass22672.95 g·mol−1
     NY (what is this?)  (verify)

    The most common side effects are abdominal or pelvic pain, bloating, as well as redness, pain or swelling at the injection site. Follitropin is possibly associated with increased risk of endometrial carcinoma. It is not for use during pregnancy, as there is evidence for birth defects under follitropin treatment.[2]

    Bravelle sold in the United States from March 2014 through October 2015 is subject to a recall and refund by its maker, Ferring Pharmaceuticals, because certain batches of the medicine had a lower strength than stated.[3]

    References
    1. van Wely M, Yding Andersen C, Bayram N, van der Veen F (2005). "Urofollitropin and ovulation induction". Treatments in Endocrinology. 4 (3): 155–65. doi:10.2165/00024677-200504030-00004. PMID 15898821.
    2. Drugs.com: Urofollitropin (Intramuscular route, Subcutaneous route, Injection route)
    3. Enforcement Report - Week of October 21, 2015, Food and Drug Administration
    • Bravelle, by Ferring Pharmaceuticals, Switzerland
    • Fostimon by Institut Biochemique SA, Switzerland
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