Peforelin

Peforelin (INN), or peforelin acetate, sold under the brand name Maprelin, is a gonadotropin-releasing hormone agonist (GnRH agonist) medication which is used in veterinary medicine in Europe and Canada.[1][2][3][4] It is a GnRH analogue and a synthetic peptide, specifically a decapeptide.[1][3][4] The drug was introduced for veterinary use by 2001.[5]

Peforelin

Clinical data
Trade names	Maprelin
Other names	Lamprey GnRH-III; H-Pyr-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2; XHWSHDWKPG
Routes of administration	Injection
Drug class	GnRH agonist
Identifiers
IUPAC name (3S)-4-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoic acid
CAS Number	147859-97-0
PubChem CID	16197823
ChemSpider	17326238
UNII	UJ8NQ5Z0VX
CompTox Dashboard (EPA)	DTXSID30163819
ECHA InfoCard	100.223.356
Chemical and physical data
Formula	C59H74N18O14
Molar mass	1259.353 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1C[C@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8)C(=O)NCC(=O)N
InChI InChI=1S/C59H74N18O14/c60-16-6-5-12-40(59(91)77-17-7-13-47(77)58(90)66-27-48(61)79)70-52(84)41(18-31-23-64-37-10-3-1-8-35(31)37)72-56(88)45(22-50(81)82)75-55(87)44(21-34-26-63-30-68-34)74-57(89)46(28-78)76-53(85)42(19-32-24-65-38-11-4-2-9-36(32)38)71-54(86)43(20-33-25-62-29-67-33)73-51(83)39-14-15-49(80)69-39/h1-4,8-11,23-26,29-30,39-47,64-65,78H,5-7,12-22,27-28,60H2,(H2,61,79)(H,62,67)(H,63,68)(H,66,90)(H,69,80)(H,70,84)(H,71,86)(H,72,88)(H,73,83)(H,74,89)(H,75,87)(H,76,85)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 Key:RTASYRSYWSLWJV-CSYZDTNESA-N

See also

• Gonadotropin-releasing hormone receptor § Agonists

References

1. https://www.drugs.com/international/peforelin.html
2. https://www.drugs.com/vet/maprelin-xp-10-can.html
3. Wolfgang Löscher; Angelika Richter; Heidrun Potschka (3 September 2014). Pharmakotherapie bei Haus- und Nutztieren: Begründet von W. Löscher, F.R. Ungemach und R. Kroker. Enke. pp. 435–. ISBN 978-3-8304-1251-9.
4. Heriberto Rodriguez-Martinez (1 April 2010). Control of Pig Reproduction VIII. Nottingham University Press. pp. 190–. ISBN 978-1-907284-53-3.
5. http://www.sgau.ru/files/pages/846/14713368000.pdf#page=48