beta-Melanocyte-stimulating hormone

β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide.[1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).[1] It is an agonist of the MC₁, MC₃, MC₄, and MC₅ receptors.[1]

Beta-Melanocyte-stimulating hormone

Names
Other names beta-MSH, β-melanotropin, β-melanocortin, β-intermedin
Identifiers
CAS Number	17908-57-5
3D model (JSmol)	Interactive image
PubChem CID	16172929
CompTox Dashboard (EPA)	DTXSID00583247
SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NCC(=O)NC(CO)C(=O)N7CCCC7C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)O)N
Properties
Chemical formula	C118H174N34O35S
Molar mass	2660.91596 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

B-melanocyte-stimulating hormone(hBMSH) is artificially generated because it does not exist in humans naturally.[2] B-melanocyte-stimulating hormone is also known to decrease food intake in animals such as rats, chicken due to the effect of Proopiomelanocortin (POMC).[3] Research was performed to see the effect B-MSH has on chicks, and it has been found that chicks responded with a decrease in food and water intake when treated with B-MSH. The experiment showed that B-MSH causes anorexigenic effects in chicks.[4]

See also

• α-Melanocyte-stimulating hormone
• γ-Melanocyte-stimulating hormone
• Adrenocorticotropic hormone

References

1. Abba Kastin (26 January 2013). Handbook of Biologically Active Peptides. Academic Press. pp. 838–844. ISBN 978-0-12-385096-6.
2. Bertagna, X; Lenne, F; Comar, D; Massias, J F; Wajcman, H; Baudin, V; Luton, J P; Girard, F (December 1986). "Human beta-melanocyte-stimulating hormone revisited". Proceedings of the National Academy of Sciences of the United States of America. 83 (24): 9719–9723. Bibcode:1986PNAS...83.9719B. doi:10.1073/pnas.83.24.9719. ISSN 0027-8424. PMC 387212. PMID 2432601.
3. Kamisoyama, Hiroshi; Honda, Kazuhisa; Saneyasu, Takaoki; Sugahara, Kunio; Hasegawa, Shin (2009-07-24). "Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks". Neuroscience Letters. 458 (3): 102–105. doi:10.1016/j.neulet.2009.04.041. ISSN 0304-3940. PMID 19393716.
4. Smith, M. L.; Prall, B.; Nandar, W.; Cline, M. A. (February 2008). "Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks". Journal of Neuroendocrinology. 20 (2): 220–226. doi:10.1111/j.1365-2826.2007.01639.x. ISSN 1365-2826. PMID 18088360.