Atypical antidepressant

An atypical antidepressant is a type of antidepressant medication which acts in an atypical manner relative to most other antidepressants. Examples of atypical antidepressants include mirtazapine, mianserin, bupropion, trazodone, nefazodone, tianeptine, opipramol, and agomelatine.[1][2][3] The agents vilazodone and vortioxetine are also partially atypical. Atypical antidepressants are as opposed to typical antidepressants like the SSRIs, SNRIs, TCAs, and MAOIs, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine.[1][2][3] Among TCAs, trimipramine is an atypical agent in that it does not appear to do this.[3]

Esketamine (JNJ-54135419) and buprenorphine/samidorphan (ALKS-5461) are antidepressants with novel mechanisms of action which are under development and, at present, would be considered to be atypical antidepressants.[4] Unlike current agents, they are more rapidly-acting antidepressants.[4]

See also

References
  1. Feighner JP (1999). "Mechanism of action of antidepressant medications". J Clin Psychiatry. 60 Suppl 4: 4–11, discussion 12–3. PMID 10086478.
  2. Stahl SM (1998). "Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action". J Clin Psychiatry. 59 Suppl 4: 5–14. PMID 9554316.
  3. Frazer A (1997). "Pharmacology of antidepressants". J Clin Psychopharmacol. 17 Suppl 1: 2S–18S. doi:10.1097/00004714-199704001-00002. PMID 9090573.
  4. Garay RP, Zarate CA, Charpeaud T, Citrome L, Correll CU, Hameg A, Llorca PM (2017). "Investigational drugs in recent clinical trials for treatment-resistant depression". Expert Rev Neurother. 17 (6): 593–609. doi:10.1080/14737175.2017.1283217. PMC 5418088. PMID 28092469.



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