Arylacetonitrilase
In enzymology, an arylacetonitrilase (EC 3.5.5.5) is an enzyme that catalyzes the chemical reaction
- 4-chlorophenylacetonitrile + 2 H2O 4-chlorophenylacetate + NH3
| arylacetonitrilase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.5.5 | ||||||||
| CAS number | 132053-06-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H2O, whereas its two products are 4-chlorophenylacetate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.
References
- Mauger J, Nagasawa T, Yamada H (1990). "Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3". Arch. Microbiol. 155: 1–6. doi:10.1007/BF00291265.
- Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization". Eur. J. Biochem. 194 (3): 765–72. doi:10.1111/j.1432-1033.1990.tb19467.x. PMID 2269298.
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