Archaeosine synthase

Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O L-glutamate + archaeine15 in tRNA
Archaeosine synthase
Identifiers
EC number2.6.1.97
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

In Euryarchaeota the reaction is catalysed by ArcS.

References

  1. Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crécy-Lagard V (April 2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry. 285 (17): 12706–13. doi:10.1074/jbc.M110.102236. PMC 2857094. PMID 20129918.
  2. Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crécy-Lagard V (February 2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology. 7 (2): 300–5. doi:10.1021/cb200361w. PMC 3289047. PMID 22032275.
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