Acetylspermidine deacetylase

In enzymology, an acetylspermidine deacetylase (EC 3.5.1.48) is an enzyme that catalyzes the chemical reaction

N8-acetylspermidine + H2O acetate + spermidine
acetylspermidine deacetylase
Identifiers
EC number3.5.1.48
CAS number67339-07-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are N8-acetylspermidine and H2O, whereas its two products are acetate and spermidine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N8-acetylspermidine amidohydrolase. Other names in common use include N8-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, N-acetylspermidine deacetylase, N1-acetylspermidine amidohydrolase (incorrect), and 8-N-acetylspermidine amidohydrolase.

References

    • Libby PR (1978). "Properties of an acetylspermidine deacetylase from rat liver". Arch. Biochem. Biophys. 188 (2): 360–3. doi:10.1016/S0003-9861(78)80020-4. PMID 28089.
    • Blankenship J (1978). "Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue". Arch. Biochem. Biophys. 189 (1): 20–7. doi:10.1016/0003-9861(78)90109-1. PMID 708044.
    • Marchant P, Manneh VA, Blankenship J (1986). "N1-acetylspermidine is not a substrate for N-acetylspermidine deacetylase". Biochim. Biophys. Acta. 881 (2): 297–9. doi:10.1016/0304-4165(86)90017-6. PMID 3955076.


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