Adiponectin receptor 2

ADIPOR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXW
Identifiers
Aliases	ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs	OMIM: 607946 MGI: 93830 HomoloGene: 56119 GeneCards: ADIPOR2
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	1,788,674 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	119,417,704 bp[2]
Gene ontology
Molecular function	• adipokinetic hormone receptor activity; • adiponectin binding; • metal ion binding; • identical protein binding; • protein heterodimerization activity; • signaling receptor activity;
Cellular component	• integral component of membrane; • membrane; • intrinsic component of plasma membrane; • cell membrane;
Biological process	• positive regulation of glucose import; • glucose homeostasis; • response to nutrient; • lipid metabolism; • female pregnancy; • adiponectin-activated signaling pathway; • fatty acid metabolic process; • vascular wound healing; • heart development; • negative regulation of cell growth; • fatty acid oxidation; • hormone-mediated signaling pathway; • regulation of fatty acid biosynthetic process; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	79602
	68465
	ENSG00000006831; ENSG00000285070
	ENSMUSG00000030168
	Q86V24
	Q8BQS5
	NM_024551; NM_001375363; NM_001375364; NM_001375365
	NM_197985; NM_001355692
	NP_078827; NP_001362292; NP_001362293; NP_001362294
	NP_932102; NP_001342621
	Wikidata
View/Edit Human	View/Edit Mouse

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[6]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5] In 2016, the University of Tokyo announced it was launching an investigation into anonymously made claims of fabricated and falsified data on the identification of AdipoR1 and AdipoR2.[7]

Ligands

Agonists

Peptide

Adiponectin
ADP-355[8]
ADP-399[8]

Non-peptide

Antagonists

Peptide

ADP-400[8]

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References

ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030168 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.
University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS One. 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

External links

Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030168 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.

[Dennis-7] University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016

[pmid25368867-8] Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.

[pmid24172895-9] Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.

[pmid23691032-10] Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS One. 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

Adiponectin receptor 2

Structure

Function

Ligands

Agonists

Peptide

Non-peptide

Antagonists

Peptide

See also

References

External links