3-hydroxymethylcephem carbamoyltransferase
In enzymology, a 3-hydroxymethylcephem carbamoyltransferase (EC 2.1.3.7) is an enzyme that catalyzes the chemical reaction
- carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate phosphate + a 3-carbamoyloxymethylcephem
| 3-hydroxymethylcephem carbamoyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.3.7 | ||||||||
| CAS number | 74315-96-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are carbamoyl phosphate and 3-hydroxymethylceph-3-em-4-carboxylate, whereas its two products are phosphate and 3-carbamoyloxymethylcephem.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase. This enzyme has at least one effector, ATP.
References
- Brewer SJ, Taylor PM, Turner MK (1980). "An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus". Biochem. J. 185 (3): 555–64. PMC 1161431. PMID 6248024.
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