2'''-acetyl-6'''-hydroxyneomycin C deacetylase

2'''-acetyl-6'''-hydroxyneomycin C deacetylase (EC 3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).[1] This enzyme catalyses the following chemical reaction

2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O 6'''-deamino-6'''-hydroxyneomycin C + acetate
2'''-acetyl-6'''-hydroxyneomycin C deacetylase
Identifiers
EC number3.5.1.113
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the [neomycin] family.

References

  1. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.
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