2'''-acetyl-6'''-hydroxyneomycin C deacetylase
2'''-acetyl-6'''-hydroxyneomycin C deacetylase (EC 3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).[1] This enzyme catalyses the following chemical reaction
- 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O 6'''-deamino-6'''-hydroxyneomycin C + acetate
| 2'''-acetyl-6'''-hydroxyneomycin C deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.113 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the [neomycin] family.
References
- Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.
External links
- 2'''-acetyl-6'''-hydroxyneomycin C deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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