(R)-limonene synthase
In enzymology, a (R)-limonene synthase (EC 4.2.3.20) is an enzyme that catalyzes the reversible chemical reaction
- geranyl diphosphate (+)-(4R)-limonene + diphosphate
| (R)-limonene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.20 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hence, this enzyme has one substrate, geranyl diphosphate, and two products, (+)-(4R)-limonene and diphosphate.
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming]. Other names in common use include (+)-limonene synthase, and geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming]. This enzyme participates in monoterpenoid biosynthesis and is localized to Leucoplasts of oil gland secretory cells.[1]
References
- Turner, Glenn; Gershenzon, Jonathan; Nielson, Erik E.; Froehlich, John E.; Croteau, Rodney (July 1999). "Limonene Synthase, the Enzyme Responsible for Monoterpene Biosynthesis in Peppermint, Is Localized to Leucoplasts of Oil Gland Secretory Cells". Plant Physiology. 120 (3): 879–886. doi:10.1104/pp.120.3.879. PMC 59327. PMID 10398724.
Further reading
- Bouwmeester, Harro J.; Gershenzon, Jonathan; Konings, Maurice C.J.M.; Croteau, Rodney (1 July 1998). "Biosynthesis of the Monoterpenes Limonene and Carvone in the Fruit of Caraway". Plant Physiology. 117 (3): 901–912. doi:10.1104/pp.117.3.901. PMID 9662532.
- Lücker, Joost; El Tamer, Mazen K.; Schwab, Wilfried; Verstappen, Francel W. A.; van der Plas, Linus H. W.; Bouwmeester, Harro J.; Verhoeven, Harrie A. (July 2002). "Monoterpene biosynthesis in lemon (Citrus limon)". European Journal of Biochemistry. 269 (13): 3160–3171. doi:10.1046/j.1432-1033.2002.02985.x. PMID 12084056.
- Maruyama, Takuro; Ito, Michiho; Kiuchi, Fumiyuki; Honda, Gisho (2001). "Molecular Cloning, Functional Expression and Characterization of d-Limonene Synthase from Schizonepeta tenuifolia". Biological & Pharmaceutical Bulletin. 24 (4): 373–377. doi:10.1248/bpb.24.373. PMID 11305598.
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