3-Hydroxyacyl ACP dehydrase

3-Hydroxyacyl ACP dehydrase is an enzyme involved in fatty acid synthesis.

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa [1]
Identifiers
Symbol	EHHADH
Alt. symbols	ECHD
NCBI gene	1962
HGNC	3247
OMIM	607037
RefSeq	NM_001966
UniProt	Q08426
Other data
EC number	4.2.1.17
Locus	Chr. 3 q26.3-q28

External links

3-Hydroxyacyl+Dehydratases at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

Metabolism: lipid metabolism / fatty acid metabolism, triglyceride and fatty acid enzymes

Synthesis

Malonyl-CoA synthesis	ATP citrate lyase Acetyl-CoA carboxylase
Fatty acid synthesis/ Fatty acid synthase	Beta-ketoacyl-ACP synthase Β-Ketoacyl ACP reductase 3-Hydroxyacyl ACP dehydrase Enoyl ACP reductase
Fatty acid desaturases	Stearoyl-CoA desaturase-1
Triacyl glycerol	Glycerol-3-phosphate dehydrogenase Thiokinase

General	Acyl CoA dehydrogenase (ACADL ACADM ACADS ACADVL ACADSB) Enoyl-CoA hydratase MTP: HADH HADHA HADHB Acetyl-CoA C-acyltransferase
Unsaturated	Enoyl CoA isomerase 2,4 Dienoyl-CoA reductase
Odd chain	Propionyl-CoA carboxylase
Other	Hydroxyacyl-Coenzyme A dehydrogenase

Malonyl-CoA decarboxylase

Long-chain-aldehyde dehydrogenase

References

"RCSB Protein Data Bank - Structure Summary for 1U1Z - The Structure of (3R)-hydroxyacyl-ACP dehydratase (FabZ)".

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