TPTE

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.[3][4]

TPTE
Identifiers
Aliases	TPTE, CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDs	OMIM: 604336 GeneCards: TPTE
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21p11.2 Start 10,521,553 bp[1] End 10,606,140 bp[1]
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • integral component of membrane • membrane Biological process • signal transduction • dephosphorylation • peptidyl-tyrosine dephosphorylation • protein dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7179	n/a
Ensembl	ENSG00000274391	n/a
UniProt	P56180	n/a
RefSeq (mRNA)	NM_199261 NM_001290224 NM_199259 NM_199260	n/a
RefSeq (protein)	NP_001277153 NP_954868 NP_954869 NP_954870	n/a
Location (UCSC)	Chr 21: 10.52 – 10.61 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[4] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipd phosphatase;[5] TPTE itself is predicted to lack phosphatase activity.[6] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

References

1. GRCh38: Ensembl release 89: ENSG00000274391 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
4. "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
5. Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.
6. Chen, Mark J.; Dixon, Jack E.; Manning, Gerard (2017-04-11). "Genomics and evolution of protein phosphatases". Sci. Signal. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. ISSN 1945-0877. PMID 28400531.

Further reading

• Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
• Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804.
• Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21" (PDF). Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409.
• Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID 11279206.
• Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family" (PDF). Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268.