PTPN4

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.[5][6]

PTPN4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDsOMIM: 176878 MGI: 1099792 HomoloGene: 2120 GeneCards: PTPN4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.2Start119,759,922 bp[1]
End119,984,899 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5775

19258

Ensembl

ENSG00000088179

ENSMUSG00000026384

UniProt

P29074

Q9WU22

RefSeq (mRNA)

NM_002830

NM_019933

RefSeq (protein)

NP_002821

NP_064317

Location (UCSC)Chr 2: 119.76 – 119.98 MbChr 1: 119.65 – 119.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[6]

Interactions

PTPN4 has been shown to interact with GRID2.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000088179 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026384 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. doi:10.1073/pnas.88.13.5867. PMC 51979. PMID 1648233.
  6. "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".
  7. Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P29074 (Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)) at the PDBe-KB.


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