MTMR6

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.[5][6]

MTMR6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YF0
Identifiers
Aliases	MTMR6, myotubularin related protein 6
External IDs	OMIM: 603561 MGI: 2145637 HomoloGene: 55842 GeneCards: MTMR6
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.13 Start 25,246,201 bp[1] End 25,288,009 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 60,265,228 bp[2] End 60,302,370 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • hydrolase activity • protein serine/threonine phosphatase activity • phosphatidylinositol phosphate phosphatase activity • calcium-activated potassium channel activity • GO:0001948 protein binding • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • phosphatidylinositol-3,5-bisphosphate phosphatase activity Cellular component • cytosol • cell nucleus • cytoplasm • nuclear envelope • endoplasmic reticulum • endoplasmic reticulum-Golgi intermediate compartment • cell membrane • membrane • ruffle membrane • cell projection • perinuclear region of cytoplasm Biological process • phosphatidylinositol biosynthetic process • protein dephosphorylation • dephosphorylation • potassium ion transmembrane transport • peptidyl-tyrosine dephosphorylation • phosphatidylinositol dephosphorylation • lipid metabolism • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9107	219135
Ensembl	ENSG00000139505	ENSMUSG00000021987
UniProt	Q9Y217	Q8VE11
RefSeq (mRNA)	NM_004685	NM_144843
RefSeq (protein)	NP_004676	NP_659092
Location (UCSC)	Chr 13: 25.25 – 25.29 Mb	Chr 14: 60.27 – 60.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MTMR6 has been shown to interact with MTMR9.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000139505 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021987 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (Dec 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
6. "Entrez Gene: MTMR6 myotubularin related protein 6".
7. Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.

Further reading

• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA (2003). "Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases". Curr. Biol. 13 (6): 504–9. doi:10.1016/S0960-9822(03)00132-5. PMID 12646134.
• Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA (2003). "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8660–5. doi:10.1073/pnas.1033097100. PMC 166368. PMID 12847286.
• Mochizuki Y, Majerus PW (2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY (2006). "Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells". Mol. Cell. Biol. 26 (15): 5595–602. doi:10.1128/MCB.00352-06. PMC 1592754. PMID 16847315.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Myotubularin-related protein 6 (MTMR6)