Small nucleolar RNA SNORA51

Small nucleolar RNA SNORA51 (also known as ACA51) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA51 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein.

Small nucleolar RNA SNORA51
Predicted secondary structure and sequence conservation of SNORA51
Identifiers
SymbolSNORA51
Alt. SymbolssnoACA51
RfamRF00432
Other data
RNA typeGene; snRNA; snoRNA; HACA-box
Domain(s)Eukaryota
GO0006396 0005730
SO0000594
PDB structuresPDBe

References

  1. Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
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