WNT7B

Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.[5][6][7][8]

WNT7B
Identifiers
Aliases	WNT7B, Wnt family member 7B
External IDs	OMIM: 601967 MGI: 98962 HomoloGene: 22531 GeneCards: WNT7B
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 45,920,366 bp[1] End 45,977,162 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E2|15 40.39 cM Start 85,535,437 bp[2] End 85,582,473 bp[2]
Gene ontology Molecular function • GO:0005110 frizzled binding • receptor binding • receptor ligand activity Cellular component • endocytic vesicle membrane • endoplasmic reticulum lumen • extracellular region • Golgi lumen • extracellular exosome • cell membrane • cytoplasm • extracellular Biological process • cellular response to retinoic acid • cell fate commitment • renal inner medulla development • lung morphogenesis • mammary gland epithelium development • stem cell proliferation • embryonic organ development • lung development • renal outer medulla development • embryonic placenta morphogenesis • synapse organization • metanephric epithelium development • in utero embryonic development • trachea cartilage morphogenesis • chorio-allantoic fusion • multicellular organism development • developmental growth involved in morphogenesis • forebrain regionalization • positive regulation of osteoblast differentiation • cell metabolism • metanephric loop of Henle development • neuron differentiation • central nervous system vasculogenesis • fibroblast proliferation • lobar bronchus development • metanephros morphogenesis • inner medullary collecting duct development • metanephric collecting duct development • establishment or maintenance of polarity of embryonic epithelium • lung epithelium development • outer medullary collecting duct development • oxygen homeostasis • lens fiber cell development • homeostatic process • regulation of cell projection size • activation of JUN kinase activity • response to glucocorticoid • neuron projection morphogenesis • Wnt signaling pathway • neuron projection development • positive regulation of JNK cascade • canonical Wnt signaling pathway • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7477	22422
Ensembl	ENSG00000188064	ENSMUSG00000022382
UniProt	P56706	P28047
RefSeq (mRNA)	NM_058238	NM_001163633 NM_001163634 NM_009528
RefSeq (protein)	NP_478679	NP_001157105 NP_001157106 NP_033554
Location (UCSC)	Chr 22: 45.92 – 45.98 Mb	Chr 15: 85.54 – 85.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.[8]

Role in kidney

Wnt7b is a key paracrine signaling factor secreted by the ureteric epithelium that establishes the cortico-medullary axis of the mammalian kidney.[9] Wnt7b is a signaling protein that plays a crucial role for many developmental processes including placental, lung, eye, dendrite, and bone formation along with kidney development. The primary role of Wnt7b is to establish the cortico-medullary axis of epithelial organization. The establishment of the cortico-medullary axis plays an essential role for the development of the medullary component of the kidney. Wnt7b regulates orientation of cell divisions in renal medullary collecting duct epithelium, in which is the major structure driving renal medulla formation. There are two interstitial regulators that are explicitly linked to medullary development; Pod1 which encodes a transcription factor expressed in the renal interstitium while p57Kip2 encodes a cyclin-dependent kinase inhibitor which is linked to Beckwith-Wiedemann syndrome. Pod1, p57Kip2 and integrin α3 (ITGA3) are three factors that are involved in renal medullary morphogenesis. The knockout of Pod1 results in no renal medullary formation while p57Kip2 and Itga3 knockouts resulted in a reduced renal medulla. Removal of Wnt7b activity leads to a failure of medullary development while other aspects of kidney development including ureteric branching, development of the renal cortex, and nephrogenesis are unaffected. The absence of renal medulla also affects the plane of epithelial cell division along with little proliferative growth of the loop of Henle. Wnt7b null allele will result in fatality due to the diminution of placental function leading to the failure to initiate organogenesis.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000188064 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022382 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (May 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Research. 54 (10): 2615–2621. PMID 8168088.
6. van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenetics and Cell Genetics. 77 (3–4): 288–289. doi:10.1159/000134600. hdl:2066/25317. PMID 9284940.
7. Kirikoshi H, Sekihara H, Katoh M (October 2001). "Molecular cloning and characterization of human WNT7B". International Journal of Oncology. 19 (4): 779–783. doi:10.3892/ijo.19.4.779. PMID 11562755.
8. "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B".
9. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP (January 2009). "A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney". Development. 136 (1): 161–171. doi:10.1242/dev.022087. PMC 2685965. PMID 19060336.

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (December 1993). "Wnt family proteins are secreted and associated with the cell surface". Molecular Biology of the Cell. 4 (12): 1267–1275. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
• Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (July 2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". European Journal of Biochemistry. 267 (13): 4300–4311. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
• Capurro MI, Shi W, Sandal S, Filmus J (December 2005). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth". The Journal of Biological Chemistry. 280 (50): 41201–41206. doi:10.1074/jbc.M507004200. PMID 16227623.