WNT11

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.[5][6]

WNT11
Identifiers
Aliases	WNT11, HWnt family member 11
External IDs	OMIM: 603699 MGI: 101948 HomoloGene: 20970 GeneCards: WNT11
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 76,186,325 bp[1] End 76,210,736 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E1|7 53.9 cM Start 98,835,112 bp[2] End 98,855,195 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0005110 frizzled binding • protein kinase activator activity • GO:0001948 protein binding • receptor binding Cellular component • extracellular region • extracellular • cytoplasm • extracellular matrix Biological process • ureteric bud morphogenesis • cellular response to retinoic acid • bone mineralization • cell differentiation • non-canonical Wnt signaling pathway • cell fate commitment • negative regulation of cartilage development • paraxial mesoderm formation • mesonephric duct development • convergent extension involved in axis elongation • positive regulation of protein kinase C signaling • kidney development • positive regulation of cell migration • ventricular septum morphogenesis • outflow tract morphogenesis • negative regulation of apoptotic process • negative regulation of cell death • adrenal gland development • planar cell polarity pathway involved in axis elongation • positive regulation of transforming growth factor beta2 production • somite development • embryonic skeletal system development • positive regulation of transcription, DNA-templated • multicellular organism development • protein phosphorylation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • maintenance of epithelial cell apical/basal polarity • positive regulation of gene expression • Wnt signaling pathway, calcium modulating pathway • negative regulation of cell migration • response to nutrient levels • protein localization to cell surface • notochord morphogenesis • negative regulation of cell growth • osteoblast differentiation • neuron differentiation • artery morphogenesis • bicellular tight junction assembly • epithelial to mesenchymal transition • positive regulation of apoptotic process • canonical Wnt signaling pathway • lung-associated mesenchyme development • negative regulation of transcription, DNA-templated • cloacal septation • negative regulation of mesenchymal cell proliferation • neuroendocrine cell differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of fibroblast growth factor production • positive regulation of stress fiber assembly • planar cell polarity pathway involved in gastrula mediolateral intercalation • Wnt signaling pathway, planar cell polarity pathway • Wnt signaling pathway • activation of protein kinase activity • cellular response to mechanical stimulus • palate development • secondary palate development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7481	22411
Ensembl	ENSG00000085741	ENSMUSG00000015957
UniProt	O96014	P48615
RefSeq (mRNA)	NM_004626	NM_001285792 NM_001285794 NM_001285795 NM_009519
RefSeq (protein)	NP_004617	NP_001272721 NP_001272723 NP_001272724 NP_033545
Location (UCSC)	Chr 11: 76.19 – 76.21 Mb	Chr 7: 98.84 – 98.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney, and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000085741 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015957 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
6. "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
• Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". Int. J. Mol. Med. 8 (6): 651–6. doi:10.3892/ijmm.8.6.651. PMID 11712081.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ouko L; Ziegler TR; Gu LH; et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". J. Biol. Chem. 279 (25): 26707–15. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim SW; Park JI; Spring CM; et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nat. Cell Biol. 6 (12): 1212–20. doi:10.1038/ncb1191. PMID 15543138.
• Koyanagi M; Haendeler J; Badorff C; et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". J. Biol. Chem. 280 (17): 16838–42. doi:10.1074/jbc.M500323200. PMID 15701629.
• Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Dev. Biol. 279 (1): 179–92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
• Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel". Nature. 466 (8): 874–878. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.