WNT2B

Protein Wnt-2b (formerly Wnt13[5]) is a protein that in humans is encoded by the WNT2B gene.[6][7][8]

WNT2B
Identifiers
Aliases	WNT2B, WNT13, Wnt family member 2B
External IDs	OMIM: 601968 MGI: 1261834 HomoloGene: 22526 GeneCards: WNT2B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 112,466,541 bp[1] End 112,530,165 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 45.88 cM Start 104,945,272 bp[2] End 104,961,921 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005110 frizzled binding • receptor binding Cellular component • extracellular region • extracellular • intracellular membrane-bounded organelle • collagen-containing extracellular matrix Biological process • cell fate commitment • positive regulation of branching involved in ureteric bud morphogenesis • male gonad development • chondrocyte differentiation • positive regulation of canonical Wnt signaling pathway • iris morphogenesis • cornea development in camera-type eye • cellular response to starvation • hematopoietic stem cell proliferation • lung induction • multicellular organism development • forebrain regionalization • lens development in camera-type eye • neuron differentiation • mesenchymal-epithelial cell signaling • canonical Wnt signaling pathway • Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7482	22414
Ensembl	ENSG00000134245	ENSMUSG00000027840
UniProt	Q93097	O70283
RefSeq (mRNA)	NM_024494 NM_001291880 NM_004185	NM_009520
RefSeq (protein)	NP_001278809 NP_004176 NP_078613	NP_033546
Location (UCSC)	Chr 1: 112.47 – 112.53 Mb	Chr 3: 104.95 – 104.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000134245 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027840 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID 12490564.
6. Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309.
7. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.
8. "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading

• Katoh M (2006). "WNT2B: comparative integromics and clinical applications (Review)". Int. J. Mol. Med. 16 (6): 1103–8. doi:10.3892/ijmm.16.6.1103. PMID 16273293.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
• Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
• Katoh M (2002). "Differential regulation of WNT2 and WNT2B expression in human cancer". Int. J. Mol. Med. 8 (6): 657–60. doi:10.3892/ijmm.8.6.657. PMID 11712082.
• Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
• Ricken A, Lochhead P, Kontogiannea M, Farookhi R (2002). "Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs". Endocrinology. 143 (7): 2741–9. doi:10.1210/en.143.7.2741. PMID 12072409.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh M (2005). "Molecular evolution of Wnt2b orthologs". Int. J. Oncol. 26 (4): 1135–9. doi:10.3892/ijo.26.4.1135. PMID 15754012.
• Struewing IT, Toborek A, Mao CD (2006). "Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites". J. Biol. Chem. 281 (11): 7282–93. doi:10.1074/jbc.M511182200. PMID 16407296.