UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135, PglF) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine hydro-lyase (configuration-retaining; UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose-forming).[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-alpha-D-glucosamine UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
Identifiers
EC number4.2.1.135
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme contains NAD+ as a cofactor.

References

  1. Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM (January 2006). "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". The Journal of Biological Chemistry. 281 (2): 723–32. doi:10.1074/jbc.m511021200. PMID 16286454.
  2. Olivier NB, Chen MM, Behr JR, Imperiali B (November 2006). "In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry. 45 (45): 13659–69. doi:10.1021/bi061456h. PMC 2542654. PMID 17087520.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.