Transfusion hemosiderosis
Transfusional hemosiderosis is the accumulation of iron in the liver and heart but also endocrine organs, in patients who receive or did receive frequent blood transfusions (such as those with thalassemia, sickle cell disease, leukemia, aplastic anemia or myelodysplastic syndrome).
| Transfusion hemosiderosis | |
|---|---|
| Specialty | Hematology |
Diagnosis
Blood transferrin test. Gold criteria is liver biopsy.
Treatment
Treatment is by phlebotomy, erythrocytapheresis or chelation therapy with iron chelating agents such as deferoxamine, deferiprone or deferasirox.[1] If iron overload has caused end-organ damage, this is generally irreversible and may require transplantation.
Society
Ted DeVita died of transfusional iron overload from too many blood transfusions.
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See also
References
- Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and Deficiency". In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel (ed.). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 229–294. doi:10.1007/978-94-007-7500-8_8.
- Lu JP, Hayashi K (1994). "Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases". Pathol. Int. 44 (3): 194–9. PMID 8025661.
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