Trans-L-3-hydroxyproline dehydratase

In enzymology, a trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) is an enzyme that catalyzes the chemical reaction

trans-L-3-hydroxyproline Delta1-pyrroline 2-carboxylate + H2O
trans-L-3-hydroxyproline dehydratase
Identifiers
EC number4.2.1.77
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, trans-L-3-hydroxyproline, and two products, Delta1-pyrroline 2-carboxylate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline-2-carboxylate-forming). This enzyme is also called trans-L-3-hydroxyproline hydro-lyase.

References

    • Ramaswamy SG (1983). "Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides". Fed. Proc. 42: 2232.
    • Visser WF, Verhoeven-Duif NM, de Koning TJ (June 2012). "Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes". The Journal of Biological Chemistry. 287 (26): 21654–62. doi:10.1074/jbc.m112.363218. PMC 3381129. PMID 22528483.


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