Tetrahymanol synthase

Tetrahymanol synthase (EC 4.2.1.123, squalenea€”tetrahymanol cyclase) is an enzyme with systematic name squalene hydro-lyase (tetrahymanol forming).[1][2] This enzyme catalyses the following chemical reaction

tetrahymanol squalene + H2O
Tetrahymanol synthase
Identifiers
EC number4.2.1.123
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The reaction occurs in the reverse direction.

This enzyme is isolated from Tetrahymena protozoans.

References

  1. Saar J, Kader JC, Poralla K, Ourisson G (September 1991). "Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila". Biochimica et Biophysica Acta (BBA) - General Subjects. 1075 (1): 93–101. doi:10.1016/0304-4165(91)90080-z. PMID 1892870.
  2. Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D (June 2005). "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis". Chemical Communications (24): 3089–91. doi:10.1039/b504300j. PMID 15959594.
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