tRNA (guanine37-N1)-methyltransferase

tRNA (guanine37-N1)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine37-N1)-methyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine37 in tRNA S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
tRNA (guanine37-N1)-methyltransferase
Identifiers
EC number2.1.1.228
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is important for the maintenance of the correct reading frame during translation.

References
  1. Takeda H, Toyooka T, Ikeuchi Y, Yokobori S, Okadome K, Takano F, Oshima T, Suzuki T, Endo Y, Hori H (December 2006). "The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus". Genes to Cells. 11 (12): 1353–65. doi:10.1111/j.1365-2443.2006.01022.x. PMID 17121543.
  2. Lee C, Kramer G, Graham DE, Appling DR (September 2007). "Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase". The Journal of Biological Chemistry. 282 (38): 27744–53. doi:10.1074/jbc.m704572200. PMID 17652090.
  3. O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brulé H, Petit C, Holmes DJ, Zalacain M, Holmes WM (April 2004). "Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth". Journal of Bacteriology. 186 (8): 2346–54. doi:10.1128/jb.186.8.2346-2354.2004. PMC 412112. PMID 15060037.
  4. Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM (July 2004). "Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein". Biochemistry. 43 (28): 9243–55. doi:10.1021/bi049671q. PMID 15248782.
  5. Goto-Ito S, Ito T, Ishii R, Muto Y, Bessho Y, Yokoyama S (September 2008). "Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5". Proteins. 72 (4): 1274–89. doi:10.1002/prot.22019. PMID 18384044.
  6. Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK (June 2003). "Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition". The EMBO Journal. 22 (11): 2593–603. doi:10.1093/emboj/cdg269. PMC 156765. PMID 12773376.
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