TAP1

Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.[5][6]

TAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JJ7
Identifiers
Aliases	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs	OMIM: 170260 MGI: 98483 HomoloGene: 495 GeneCards: TAP1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,845,209 bp[1] End 32,853,978 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,187,553 bp[2] End 34,197,225 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • MHC protein binding • nucleotide binding • protein homodimerization activity • ATPase-coupled peptide transmembrane transporter activity • TAP2 binding • MHC class Ib protein binding • ATPase activity • GO:0001948 protein binding • MHC class I protein binding • TAP1 binding • ATP binding • peptide antigen binding • ADP binding • ATPase activity, coupled to transmembrane movement of substances • peptide antigen-transporting ATPase activity • peptide transmembrane transporter activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • TAP complex • integral component of endoplasmic reticulum membrane • mitochondrion • endoplasmic reticulum • microtubule organizing center • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • MHC class I peptide loading complex Biological process • defense response • adaptive immune response • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class I • protein transport • peptide transport • GO:0022415 viral process • cytosol to ER transport • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6890	21354
Ensembl	ENSG00000226173 ENSG00000168394 ENSG00000224212 ENSG00000230705 ENSG00000206297 ENSG00000227816 ENSG00000224748 ENSG00000232367	ENSMUSG00000037321
UniProt	Q03518	P21958
RefSeq (mRNA)	NM_001292022 NM_000593	NM_001161730 NM_013683
RefSeq (protein)	NP_000584 NP_001278951	NP_001155202 NP_038711
Location (UCSC)	Chr 6: 32.85 – 32.85 Mb	Chr 17: 34.19 – 34.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[7]

See also

• ATP-binding cassette transporter

Interactions

TAP1 has been shown to interact with:

• HLA-A,[8] and
• Tapasin.[8][9]

References

1. ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 GRCh38: Ensembl release 89: ENSG00000226173, ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037321 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–173. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
6. Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–10098. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
7. "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)".
8. Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P (May 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–18271. doi:10.1074/jbc.M201388200. PMID 11884415.
9. Raghuraman G, Lapinski PE, Raghavan M (Nov 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. 277 (44): 41786–41794. doi:10.1074/jbc.M207128200. PMID 12213826.

Further reading

• Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. doi:10.1006/scel.1993.1007. PMID 8453065.
• Schölz C, Tampé R (2006). "The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms". J. Bioenerg. Biomembr. 37 (6): 509–515. doi:10.1007/s10863-005-9500-1. PMID 16691491.
• Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–441. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
• Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–3936. doi:10.1073/pnas.89.9.3932. PMC 525605. PMID 1570316.
• Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature. 348 (6303): 741–744. doi:10.1038/348741a0. PMID 2259383.
• Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R (1991). "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway". Nature. 348 (6303): 744–747. doi:10.1038/348744a0. PMID 2259384.
• Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, Gotch F, Townsend A (1990). "Presentation of viral antigen controlled by a gene in the major histocompatibility complex". Nature. 345 (6274): 449–452. doi:10.1038/345449a0. PMID 2342577.
• Szafer F, Oksenberg JR, Steinman L (1994). "New allelic polymorphisms in TAP genes". Immunogenetics. 39 (5): 374. doi:10.1007/BF00189240. PMID 8168860.
• Jackson DG, Capra JD (1994). "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11079–11083. doi:10.1073/pnas.90.23.11079. PMC 47925. PMID 8248212.
• Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–866. doi:10.1002/eji.1830230414. PMID 8458375.
• Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
• Chen HL, Gabrilovich D, Tampé R, Girgis KR, Nadaf S, Carbone DP (1996). "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer". Nat. Genet. 13 (2): 210–213. doi:10.1038/ng0696-210. PMID 8640228.
• Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–3255. PMC 451885. PMID 8670825.
• Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–883. doi:10.1016/S0960-9822(02)00611-5. PMID 8805302.
• Nijenhuis M, Hämmerling GJ (1997). "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site". J. Immunol. 157 (12): 5467–5477. PMID 8955196.
• Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ (1997). "Antigen processing and presentation by human trophoblast-derived cell lines". J. Immunol. 158 (8): 3587–3592. PMID 9103419.
• Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K (1997). "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP". Immunity. 6 (5): 613–621. doi:10.1016/S1074-7613(00)80349-0. PMID 9175839.

External links

• TAP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.