ABCA8

ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene.[5]

ABCA8
Identifiers
Aliases	ABCA8, ATP binding cassette subfamily A member 8
External IDs	OMIM: 612505 MGI: 1351668 HomoloGene: 56029 GeneCards: ABCA8
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,867,289 bp[1] End 68,955,392 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 72.88 cM Start 109,932,190 bp[2] End 109,995,845 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ATPase activity • ATP binding • xenobiotic-transporting ATPase activity • ATPase activity, coupled to transmembrane movement of substances • lipid transporter activity Cellular component • integral component of membrane • cell membrane • membrane • mitochondrial inner membrane • intracellular membrane-bounded organelle Biological process • lipid transport • xenobiotic transport • drug transmembrane transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10351	27404
Ensembl	ENSG00000141338	ENSMUSG00000020620
UniProt	O94911	Q8K440
RefSeq (mRNA)	NM_001288985 NM_001288986 NM_007168 NM_001375771 NM_001375772	NM_013851 NM_001362749
RefSeq (protein)	NP_001275914 NP_001275915 NP_009099 NP_001362700 NP_001362701	NP_038879 NP_001349678
Location (UCSC)	Chr 17: 68.87 – 68.96 Mb	Chr 11: 109.93 – 110 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000141338 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020620 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tsuruoka S, Ishibashi K, Yamamoto H, et al. (2002). "Functional analysis of ABCA8, a new drug transporter". Biochem. Biophys. Res. Commun. 298 (1): 41–5. doi:10.1016/S0006-291X(02)02389-6. PMID 12379217.
• Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8". J. Hum. Genet. 47 (6): 285–310. doi:10.1007/s100380200041. PMID 12111378.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• ABCA8 human gene location in the UCSC Genome Browser.
• ABCA8 human gene details in the UCSC Genome Browser.