Scytalone dehydratase
In enzymology, a scytalone dehydratase (EC 4.2.1.94) is an enzyme that catalyzes the chemical reaction
- scytalone 1,3,8-trihydroxynaphthalene + H2O
scytalone dehydratase | |||||||||
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Identifiers | |||||||||
EC number | 4.2.1.94 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Hence, this enzyme has one substrate, scytalone, and two products, 1,3,8-trihydroxynaphthalene and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1IDP, 1STD, 2STD, 3STD, 4STD, 5STD, 6STD, and 7STD.
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References
- Butler MJ, Lazarovits G, Higgins VJ, Lachance MA (1988). "Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi". Exp. Mycol. 12 (4): 367–376. doi:10.1016/0147-5975(88)90028-X.
- Tajima S, Kubo Y, Furusawa I, Shishiyama J (1989). "Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus". Exp. Mycol. 13: 69. doi:10.1016/0147-5975(89)90009-1.
- Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.
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