Sabinene-hydrate synthase

In enzymology, a sabinene-hydrate synthase (EC 4.2.3.11) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H2O sabinene hydrate + diphosphate
sabinene-hydrate synthase
Identifiers
EC number4.2.3.11
CAS number166800-09-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are geranyl diphosphate and H2O, whereas its two products are sabinene hydrate and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming). This enzyme is also called sabinene hydrate cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

    • Hallahan TW, Croteau R (1988). "Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis)". Arch. Biochem. Biophys. 264 (2): 618–31. doi:10.1016/0003-9861(88)90328-1. PMID 3401015.
    • Hallahan TW, Croteau R (1989). "Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate". Arch. Biochem. Biophys. 269 (1): 313–26. doi:10.1016/0003-9861(89)90113-6. PMID 2916845.


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