SNX3

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.[5][6]

SNX3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNX3, Grd19, MCOPS8, SDP3, sorting nexin 3
External IDsOMIM: 605930 MGI: 1860188 HomoloGene: 36144 GeneCards: SNX3
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q21Start108,211,222 bp[1]
End108,261,246 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8724

54198

Ensembl

ENSG00000112335

ENSMUSG00000019804

UniProt

O60493

O70492

RefSeq (mRNA)

NM_152828
NM_001300928
NM_001300929
NM_003795
NM_152827

NM_017472

RefSeq (protein)

NP_001287857
NP_001287858
NP_003786
NP_690040

n/a

Location (UCSC)Chr 6: 108.21 – 108.26 MbChr 10: 42.5 – 42.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000112335 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019804 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
  6. "Entrez Gene: SNX3 sorting nexin 3".

Further reading



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