SNX27

Sorting nexin family member 27, also known as SNX27, is a human gene.[5]

SNX27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HAS
Identifiers
Aliases	SNX27, MRT1, MY014, sorting nexin family member 27, sorting nexin 27
External IDs	OMIM: 611541 MGI: 1923992 HomoloGene: 12797 GeneCards: SNX27
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,612,006 bp[1] End 151,699,091 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 94,497,544 bp[2] End 94,582,716 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol-3-phosphate binding • GO:0001948 protein binding • phosphatidylinositol binding • lipid binding Cellular component • early endosome membrane • membrane • nucleoplasm • Retromer • early endosome • immunological synapse • WASH complex • cytoplasm • endosome • cytosol Biological process • establishment of natural killer cell polarity • endosome to lysosome transport • endosomal transport • protein transport • intracellular protein transport • retrograde transport, endosome to plasma membrane • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81609	76742
Ensembl	ENSG00000143376	ENSMUSG00000028136
UniProt	Q96L92	Q3UHD6
RefSeq (mRNA)	NM_030918 NM_001330723	NM_001082484 NM_029721
RefSeq (protein)	NP_001317652 NP_112180	NP_001075953 NP_083997
Location (UCSC)	Chr 1: 151.61 – 151.7 Mb	Chr 3: 94.5 – 94.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000143376 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028136 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SNX27 sorting nexin family member 27".

Further reading

• Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (July 2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
• Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
• Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
• MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.