SNX26

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.[5][6][7]

ARHGAP33
Identifiers
Aliases	ARHGAP33, NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33
External IDs	OMIM: 614902 MGI: 2673998 HomoloGene: 76448 GeneCards: ARHGAP33
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,774,532 bp[1] End 35,788,822 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,522,226 bp[2] End 30,535,060 bp[2]
Gene ontology Molecular function • phosphatidylinositol binding • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • protein kinase binding Cellular component • cytosol • cytoplasm • cell membrane • cell cortex • actin cytoskeleton • macromolecular complex • dendritic spine Biological process • regulation of small GTPase mediated signal transduction • protein transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • signal transduction • small GTPase mediated signal transduction • response to toxic substance • regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115703	233071
Ensembl	ENSG00000004777	ENSMUSG00000036882
UniProt	O14559	Q80YF9
RefSeq (mRNA)	NM_001172630 NM_052948 NM_001366178	NM_001289670 NM_001289682 NM_178252
RefSeq (protein)	NP_001166101 NP_443180 NP_001353107	NP_001276599 NP_001276611 NP_839983
Location (UCSC)	Chr 19: 35.77 – 35.79 Mb	Chr 7: 30.52 – 30.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000004777 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036882 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peck J, Douglas G IV, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
6. Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
7. "Entrez Gene: SNX26 sorting nexin 26".

Further reading

• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chiang SH, Hwang J, Legendre M, et al. (2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport". EMBO J. 22 (11): 2679–91. doi:10.1093/emboj/cdg262. PMC 156759. PMID 12773384.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu H, Nakazawa T, Tezuka T, Yamamoto T (2006). "Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP". J. Biol. Chem. 281 (33): 23611–9. doi:10.1074/jbc.M511205200. PMID 16777849.