SERPINB6

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.[5][6][7]

SERPINB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M37
Identifiers
Aliases	SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6
External IDs	OMIM: 173321 MGI: 103123 HomoloGene: 20956 GeneCards: SERPINB6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 2,948,159 bp[1] End 2,972,165 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.3|13 14.0 cM Start 33,917,918 bp[2] End 34,002,794 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • protease binding • serine-type endopeptidase inhibitor activity Cellular component • cytoplasm • cytosol • extracellular exosome • cell nucleus • extracellular • cell membrane • secretory granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • extracellular region • collagen-containing extracellular matrix • serine protease inhibitor complex Biological process • negative regulation of peptidase activity • sensory perception of sound • cellular response to osmotic stress • negative regulation of endopeptidase activity • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5269	20719
Ensembl	ENSG00000124570	ENSMUSG00000060147
UniProt	P35237	Q60854
RefSeq (mRNA)	NM_001195291 NM_001271822 NM_001271823 NM_001271824 NM_001271825 NM_001297699 NM_001297700 NM_004568 NM_001374515 NM_001374516 NM_001374517	NM_001164117 NM_001164118 NM_001243192 NM_009254
RefSeq (protein)	NP_001182220 NP_001258751 NP_001258752 NP_001258753 NP_001258754 NP_001284628 NP_001284629 NP_004559 NP_001361444 NP_001361445 NP_001361446	NP_001157589 NP_001157590 NP_001230121 NP_033280
Location (UCSC)	Chr 6: 2.95 – 2.97 Mb	Chr 13: 33.92 – 34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000124570 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060147 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
6. Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
7. "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

Further reading

• Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
• Coughlin P, Nicholl J, Sun J, et al. (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
• Morgenstern KA, Sprecher C, Holth L, et al. (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
• Morgenstern KA, Henzel WJ, Baker JB, et al. (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. PMID 8408007.
• Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. PMID 8486644.
• Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
• Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
• Scott FL, Paddle-Ledinek JE, Cerruti L, et al. (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
• Mikolajczyk SD, Millar LS, Marker KM, et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
• Saedi MS, Zhu Z, Marker K, et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strik MC, Wolbink A, Wouters D, et al. (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Charron Y, Madani R, Nef S, et al. (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.011
• SERPINB6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)