SERPINI2

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[5][6]

SERPINI2
Identifiers
Aliases	SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDs	OMIM: 605587 MGI: 1915181 HomoloGene: 21248 GeneCards: SERPINI2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.1 Start 167,441,789 bp[1] End 167,479,004 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 75,242,370 bp[2] End 75,270,078 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • GO:0001948 protein binding • serine-type endopeptidase inhibitor activity Cellular component • extracellular region • extracellular exosome • extracellular Biological process • movement of cell or subcellular component • negative regulation of peptidase activity • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5276	67931
Ensembl	ENSG00000114204	ENSMUSG00000034139
UniProt	O75830	Q9JK88
RefSeq (mRNA)	NM_006217 NM_001012303	NM_026460
RefSeq (protein)	NP_001012303 NP_006208	NP_080736
Location (UCSC)	Chr 3: 167.44 – 167.48 Mb	Chr 3: 75.24 – 75.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000114204 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034139 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (July 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes, Chromosomes & Cancer. 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529.
6. "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2".

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Xiao G, Liu YE, Gentz R, Sang QA, Ni J, Goldberg ID, Shi YE (March 1999). "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3700–5. doi:10.1073/pnas.96.7.3700. PMC 22357. PMID 10097100.
• Chang WS, Chang NT, Lin SC, Wu CW, Wu FY (November 2000). "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26". Genes, Chromosomes & Cancer. 29 (3): 240–55. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A. PMID 10992299.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.026