Severe acute respiratory syndrome coronavirus

Severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1)[2] is a strain of virus that causes severe acute respiratory syndrome (SARS).[3] It is an enveloped, positive-sense, single-stranded RNA virus which infects the epithelial cells within the lungs.[4] The virus enters the host cell by binding to angiotensin-converting enzyme 2.[5] It infects humans, bats, and palm civets.[6][7]

This article is about the virus strain that causes SARS. For the strain that causes COVID-19, see severe acute respiratory syndrome coronavirus 2. For the species to which both strains belong, see severe acute respiratory syndrome–related coronavirus.

Severe acute respiratory syndrome coronavirus
Electron microscope image of SARS virion
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Species: Severe acute respiratory syndrome-related coronavirus
Strain:
Severe acute respiratory syndrome coronavirus
Synonyms
  • SARS coronavirus
  • SARS-related coronavirus
  • Severe acute respiratory syndrome coronavirus[1]

On 16 April 2003, following the outbreak of SARS in Asia and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that the coronavirus identified by a number of laboratories was the official cause of SARS. The Centers for Disease Control and Prevention (CDC) in the United States and National Microbiology Laboratory (NML) in Canada identified the SARS-CoV-1 genome in April 2003.[8][9] Scientists at Erasmus University in Rotterdam, the Netherlands, demonstrated that the SARS coronavirus fulfilled Koch's postulates thereby confirming it as the causative agent. In the experiments, macaques infected with the virus developed the same symptoms as human SARS victims.[10]

A similar virus was discovered in January, 2020. This virus, named Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of the ongoing COVID-19 pandemic.[11]

SARS
Scanning electron micrograph of SARS virions

Severe acute respiratory syndrome (SARS) is the disease caused by SARS-CoV-1. It causes an often severe illness and is marked initially by systemic symptoms of muscle pain, headache, and fever, followed in 2–14 days by the onset of respiratory symptoms,[12] mainly cough, dyspnea, and pneumonia. Another common finding in SARS patients is a decrease in the number of lymphocytes circulating in the blood.[13]

In the SARS outbreak of 2003, about 9% of patients with confirmed SARS-CoV-1 infection died.[14] The mortality rate was much higher for those over 60 years old, with mortality rates approaching 50% for this subset of patients.[14]

History
Transmission of SARS-CoV-1-1 from mammals as biological carriers to humans

On 17 March 2003, WHO established a global network of leading laboratories to collaborate in the identification of the causative agent of SARS. Early on, labs in the network narrowed the search to members of the paramyxovirus and coronavirus families. Early findings shared by the labs pointed to coronaviruses with increasing consistency. On 21 March, scientists from the University of Hong Kong announced the isolation of a new virus that was strongly suspected to be the causative agent of SARS.[15]

On 12 April, scientists working at the Michael Smith Genome Sciences Centre in Vancouver finished mapping the genetic sequence of a coronavirus believed to be linked to SARS. The team was led by Marco Marra and worked in collaboration with the British Columbia Centre for Disease Control and the National Microbiology Laboratory in Winnipeg, Manitoba, using samples from infected patients in Toronto. The map, hailed by the WHO as an important step forward in fighting SARS, is shared with scientists worldwide via the GSC website (see below). Donald Low of Mount Sinai Hospital in Toronto described the discovery as having been made with "unprecedented speed".[16] The sequence of the SARS coronavirus has since been confirmed by other independent groups.

Molecular epidemiological research demonstrated the virus of 2002–2003 south China outbreak and the virus isolated in the same area in late 2003 and early 2004 outbreaks are different, indicating separate species-crossing events.[17] The phylogeny of the outbreak strains shows that the southwestern provinces including Yunnan, Guizhou and Guangxi compare to the human SARS-CoV-1 better than those of the other provinces, but the viruses' evolution is a product of the host interaction and particularity.[18]

In late May 2003, studies from samples of wild animals sold as food in the local market in Guangdong, China, found a strain of SARS coronavirus could be isolated from masked palm civets (Paguma sp.), but the animals did not always show clinical signs. The preliminary conclusion was the SARS virus crossed the xenographic barrier from palm civet to humans, and more than 10,000 masked palm civets were killed in Guangdong Province. The virus was also later found in raccoon dogs (Nyctereuteus sp.), ferret badgers (Melogale spp.), and domestic cats. In 2005, two studies identified a number of SARS-like coronaviruses in Chinese bats.[19][20] Although the bat SARS virus did not replicate in cell culture, in 2008, American researchers[21] altered the genetic structure of bat SARS virus with the human receptor binding domain both in the bat virus and in the mice which demonstrated how zoonosis might occur in evolution.[22] Phylogenetic analysis of these viruses indicated a high probability that SARS coronavirus originated in bats and spread to humans either directly or through animals held in Chinese markets. The bats did not show any visible signs of disease, but are the likely natural reservoirs of SARS-like coronaviruses. In late 2006, scientists from the Chinese Centre for Disease Control and Prevention of University of Hong Kong and the Guangzhou Centre for Disease Control and Prevention established a genetic link between the SARS coronavirus appearing in civets and humans, confirming claims that the virus had jumped across species.[23]

Virology

SARS-CoV-1 follows the replication strategy typical of the coronavirus subfamily. The primary human receptor of the virus is angiotensin-converting enzyme 2 (ACE2), first identified in 2003.[24]

Human SARS-CoV-1 appears to have had a complex history of recombination between ancestral coronaviruses that were hosted in several different animal groups.[25][26] In order for recombination to happen at least two SARS-CoV-1 genomes must be present in the same host cell. Recombination may occur during genome replication when the RNA polymerase switches from one template to another (copy choice recombination).[26]

SARS-CoV-1 is one of seven known coronaviruses to infect humans. The other six are[27]:

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See also

Notes
  1. "ICTV Taxonomy history: Severe acute respiratory syndrome-related coronavirus" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 2019-01-27.
  2. Neeltje van Doremalen; Trenton Bushmaker; Dylan H. Morris; Myndi G. Holbrook; Amandine Gamble; Brandi N. Williamson; Azaibi Tamin; Jennifer L. Harcourt; Natalie J. Thornburg; Susan I. Gerber; James O. Lloyd-Smith; Emmie de Wit; Vincent J. Munster (2020-03-17). "Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1". The New England Journal of Medicine. 382 (16): 1564–1567. doi:10.1056/NEJMc2004973. PMC 7121658. PMID 32182409.
  3. Thiel, V., ed. (2007). Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-16-5.
  4. Fehr, Anthony R.; Perlman, Stanley (2015). "Coronaviruses: An Overview of Their Replication and Pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Clifton, New Jersey, USA. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2437-0. ISSN 1064-3745. PMC 4369385. PMID 25720466. SARS-CoV primarily infects epithelial cells within the lung. The virus is capable of entering macrophages and dendritic cells but only leads to an abortive infection [87,88].
  5. Xing-Yi Ge; Jia-Lu Li; Xing-Lou Yang; et al. (2013). "Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor". Nature. 503 (7477): 535–538. Bibcode:2013Natur.503..535G. doi:10.1038/nature12711. PMC 5389864. PMID 24172901.
  6. Wong, Antonio C. P.; Li, Xin; Lau, Susanna K. P.; Woo, Patrick C. Y. (2019-02-20). "Global Epidemiology of Bat Coronaviruses". Viruses. 11 (2): 174. doi:10.3390/v11020174. ISSN 1999-4915. PMC 6409556. PMID 30791586. Most notably, horseshoe bats were found to be the reservoir of SARS-like CoVs, while palm civet cats are considered to be the intermediate host for SARS-CoVs [43,44,45].
  7. Li, Fang (October 2013). "Receptor recognition and cross-species infections of SARS coronavirus". Antiviral Research. 100 (1): 246–254. doi:10.1016/j.antiviral.2013.08.014. ISSN 0166-3542. PMC 3840050. PMID 23994189. See Figure 6.
  8. "Remembering SARS: A Deadly Puzzle and the Efforts to Solve It". Centers for Disease Control and Prevention. 2013-04-11. Archived from the original on 2013-08-01. Retrieved 2013-08-03.
  9. "Coronavirus never before seen in humans is the cause of SARS". United Nations World Health Organization. 2006-04-16. Archived from the original on 2004-08-12. Retrieved 2006-07-05.
  10. Fouchier, R. A.; Kuiken, T.; Schutten, M.; et al. (2003). "Aetiology: Koch's postulates fulfilled for SARS virus". Nature. 423 (6937): 240. Bibcode:2003Natur.423..240F. doi:10.1038/423240a. PMC 7095368. PMID 12748632.
  11. Lau, Susanna K. P.; Luk, Hayes K. H.; Wong, Antonio C. P.; Li, Kenneth S. M.; Zhu, Longchao; He, Zirong; Fung, Joshua; Chan, Tony T. Y.; Fung, Kitty S. C.; Woo, Patrick C. Y. (2020). "Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2 - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC". Emerg Infect Dis. 26 (7): 1542–1547. doi:10.3201/eid2607.200092. Retrieved 2020-08-01.
  12. Chan-Yeung, M.; Xu, R. H. (November 2003). "SARS: epidemiology". Respirology. Carlton, Victoria, USA. 8 (Suppl): S9–S14. doi:10.1046/j.1440-1843.2003.00518.x. PMC 7169193. PMID 15018127.
  13. Yang, M.; Li, C. K.; Li, K.; Hon, K. L.; Ng, M. H.; Chan, P. K.; Fok, T. F. (August 2004). "Hematological findings in SARS patients and possible mechanisms". International Journal of Molecular Medicine (review). 14 (2): 311–315. doi:10.3892/ijmm.14.2.311. PMID 15254784. Archived from the original on 2015-09-24.
  14. Sørensen, M. D.; Sørensen, B.; Gonzalez-Dosal, R.; Melchjorsen, C. J.; Weibel, J.; Wang, J.; Jun, C. W.; Huanming, Y.; Kristensen, P. (May 2006). "Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals". Annals of the New York Academy of Sciences. 1067 (1): 500–505. Bibcode:2006NYASA1067..500S. doi:10.1196/annals.1354.072. PMC 7167626. PMID 16804033.
  15. "Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak - Update 12". WHO. 2003-03-27.
  16. "B.C. lab cracks suspected SARS code". Canada: CBC News. April 2003. Archived from the original on 2007-11-26.
  17. Wang, Lin-Fa et al. “Review of bats and SARS.” Emerging Infectious Diseases vol. 12,12 (2006): 1834-40. National Library of Medicine website doi:10.3201/eid1212.060401
  18. Yu, Ping et al. “Geographical structure of bat SARS-related coronaviruses.” Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases vol. 69 (2019): 224-229. National Library of Medicine website doi:10.1016/j.meegid.2019.02.001
  19. Li, W.; Shi, Z.; Yu, M.; et al. (2005). "Bats are natural reservoirs of SARS-like coronaviruses". Science. 310 (5748): 676–679. Bibcode:2005Sci...310..676L. doi:10.1126/science.1118391. PMID 16195424. S2CID 2971923.
  20. Lau, S. K.; Woo, P. C.; Li, K. S.; et al. (2005). "Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats". Proceedings of the National Academy of Sciences of the United States of America. 102 (39): 14040–14045. Bibcode:2005PNAS..10214040L. doi:10.1073/pnas.0506735102. PMC 1236580. PMID 16169905.
  21. Becker, Michelle M et al. “Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.” Proceedings of the National Academy of Sciences of the United States of America vol. 105,50 (2008): 19944-9. doi:10.1073/pnas.0808116105. National Library of Medicine website Retrieved 13 April 2020.
  22. National Academies of Sciences, Engineering, and Medicine, Division on Earth and Life Studies, Board on Life Sciences, Board on Chemical Sciences and Technology, Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology. (5 December 2018). Biodefense in the Age of Synthetic Biology. Washington, DC: National Academies Press. pp. 44-45. ISBN 978-0-309-46518-2 DOI 10.17226/24890. Google Books. Retrieved 13 April 2020.
  23. "Scientists prove SARS-civet cat link". China Daily. 2006-11-23. Archived from the original on 2011-06-14.
  24. Li, Wenhui; Moore, Michael J.; Vasilieva, Natalya; Sui, Jianhua; Wong, Swee Kee; Berne, Michael A.; Somasundaran, Mohan; Sullivan, John L.; Luzuriaga, Katherine; Greenough, Thomas C.; Choe, Hyeryun (November 2003). "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus". Nature. 426 (6965): 450–454. Bibcode:2003Natur.426..450L. doi:10.1038/nature02145. ISSN 0028-0836. PMC 7095016. PMID 14647384.
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  26. Zhang XW, Yap YL, Danchin A. Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus. Arch Virol. 2005 Jan;150(1):1-20. Epub 2004 Oct 11. PMID: 15480857
  27. Leung, Daniel. "Coronaviruses (including SARS)". Infectious Disease Advisor. Decision Support in Medicine, LLC. Retrieved 2020-08-01.

References
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