S-specific spore photoproduct lyase
S-specific spore photoproduct lyase (EC 4.1.99.15, SAM, SP lyase, SPL, SplB, SplG) is an enzyme with systematic name S-specific spore photoproduct pyrimidine-lyase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (5S)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in DNA) + S-adenosyl-L-methionine thymidylyl-(3'->5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine
| S-specific spore photoproduct lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.99.15 | ||||||||
| CAS number | 37290-70-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is an iron-sulfur protein.
References
- Chandor A, Berteau O, Douki T, Gasparutto D, Sanakis Y, Ollagnier-de-Choudens S, Atta M, Fontecave M (September 2006). "Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis". The Journal of Biological Chemistry. 281 (37): 26922–31. doi:10.1074/jbc.m602297200. PMID 16829676.
- Pieck JC, Hennecke U, Pierik AJ, Friedel MG, Carell T (November 2006). "Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates". The Journal of Biological Chemistry. 281 (47): 36317–26. doi:10.1074/jbc.m607053200. PMID 16968710.
- Mehl RA, Begley TP (October 1999). "Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct". Organic Letters. 1 (7): 1065–6. doi:10.1021/ol9908676. PMID 10825958.
- Friedel MG, Berteau O, Pieck JC, Atta M, Ollagnier-de-Choudens S, Fontecave M, Carell T (January 2006). "The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion" (PDF). Chemical Communications (4): 445–7. doi:10.1039/b514103f. PMID 16493831.
External links
- S-specific+spore+photoproduct+lyase at the US National Library of Medicine Medical Subject Headings (MeSH)
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