2-hydroxyphytanoyl-CoA lyase
2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[1]
2-hydroxyacyl-CoA lyase 1 | |
---|---|
Identifiers | |
Symbol | HACL1 |
Alt. symbols | HPCL |
NCBI gene | 26061 |
HGNC | 17856 |
OMIM | 604300 |
RefSeq | NM_012260 |
UniProt | Q9UJ83 |
Other data | |
Locus | Chr. 3 p24.3 |
It is classified under EC number 4.1.
References
- Foulon V, Antonenkov V, Croes K, et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
External links
Media related to 2-hydroxyphytanoyl-CoA lyase at Wikimedia Commons - 2-hydroxyphytanoyl-coenzyme+A+lyase at the US National Library of Medicine Medical Subject Headings (MeSH)
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