Rhamnulose-1-phosphate aldolase

In enzymology, a rhamnulose-1-phosphate aldolase (EC 4.1.2.19) is an enzyme that catalyzes the chemical reaction

L-rhamnulose 1-phosphate glycerone phosphate + (S)-lactaldehyde
rhamnulose-1-phosphate aldolase
Identifiers
EC number4.1.2.19
CAS number9054-58-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, L-rhamnulose 1-phosphate, and two products, glycerone phosphate and (S)-lactaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-rhamnulose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include rhamnulose phosphate aldolase, L-rhamnulose 1-phosphate aldolase, L-rhamnulose-phosphate aldolase, and L-rhamnulose-1-phosphate lactaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1GT7 and 1OJR.

gollark: That reminds me, I really ought to see what CraftOS-PC raw mode looks like now.
gollark: Or I could make some sort of horrible very limited CraftOS-PC reimplementation based on the actual Lua library, magically copy whatever OC does, and just make all the `term` calls print TRoR output instead.
gollark: no.
gollark: Hmm, maybe you could get persistence out of CraftOS-PC somehow.
gollark: Well, it would mostly be a somewhat useless shiny toy™, but you could do cool things like remote into it from two devices at once, hook it up to ingame peripherals via some other interface and control it from the browser, or maybe even connect up HTTP listeners.

References
    • Chiu TH, Feingold DS (1969). "L-rhamnulose 1-phosphate aldolase from Escherichia coli Crystallization and properties". Biochemistry. 8 (1): 98–108. doi:10.1021/bi00829a015. PMID 4975916.
    • Sawada H; Takagi Y (1964). "The metabolism of L-rhamnose in Escherichia coli. 3 L-Rhamulose-phosphate aldolase". Biochim. Biophys. Acta. 92: 26–32. doi:10.1016/0926-6569(64)90265-2. PMID 14243785.


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