Pyrrole-2-carboxylate decarboxylase

Pyrrole-2-carboxylate decarboxylase (EC 4.1.1.93) is an enzyme with systematic name pyrrole-2-carboxylate carboxy-lyase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) pyrrole-2-carboxylate pyrrole + CO2
(2) pyrrole-2-carboxylate + H2O pyrrole + HCO3
Pyrrole-2-carboxylate decarboxylase
Identifiers
EC number4.1.1.93
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme catalyses both the carboxylation and decarboxylation reactions.

References

  1. Wieser M, Fujii N, Yoshida T, Nagasawa T (October 1998). "Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910". European Journal of Biochemistry. 257 (2): 495–9. doi:10.1046/j.1432-1327.1998.2570495.x. PMID 9826198.
  2. Omura H, Wieser M, Nagasawa T (April 1998). "Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme". European Journal of Biochemistry. 253 (2): 480–4. doi:10.1046/j.1432-1327.1998.2530480.x. PMID 9654100.
  3. Wieser, M.; Yoshida, T.; Nagasawa, T. (1998). "Microbial synthesis of pyrrole-2-carboxylate by Bacillus megaterium PYR2910". Tetrahedron Lett. 39: 4309–4310. doi:10.1016/s0040-4039(98)00718-7.
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