Protocatechuate decarboxylase

In enzymology, a protocatechuate decarboxylase (EC 4.1.1.63) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxybenzoate catechol + CO2
protocatechuate decarboxylase
Identifiers
EC number4.1.1.63
CAS number37290-55-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, 3,4-dihydroxybenzoate, and two products, catechol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3,4-dihydroxybenzoate carboxy-lyase (catechol-forming). Other names in common use include 3,4-dihydrobenzoate decarboxylase, and protocatechuate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.

References

    • Grant DJ, Patel JC (1969). "The non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". Antonie van Leeuwenhoek. 35 (3): 325–43. doi:10.1007/BF02219153. PMID 5309907.


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