Presilphiperfolanol synthase

Presilphiperfolanol synthase (EC 4.2.3.74, BcBOT2, CND15) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8beta-ol-forming).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O presilphiperfolan-8beta-ol + diphosphate
Presilphiperfolanol synthase
Identifiers
EC number4.2.3.74
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires Mg2+.

References

  1. Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pêcheur P, Morgant G, Collado IG, Cane DE, Viaud M (2008). "Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea". ACS Chem. Biol. 3 (12): 791–801. doi:10.1021/cb800225v. PMC 2707148. PMID 19035644.
  2. Wang CM, Hopson R, Lin X, Cane DE (2009). "Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol". J. Am. Chem. Soc. 131 (24): 8360–1. doi:10.1021/ja9021649. PMC 2702122. PMID 19476353.
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