Phosphomannomutase

In enzymology, a phosphomannomutase (EC 5.4.2.8) is an enzyme that catalyzes the chemical reaction

alpha-D-mannose 1-phosphate D-mannose 6-phosphate
phosphomannomutase
phosphomannomutase 1, dimer, Human
Identifiers
EC number5.4.2.8
CAS number59536-73-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-mannose 1,6-phosphomutase. Other names in common use include mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This enzyme participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.

Structural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1K2Y, 1WQA, 2AMY, 2F7L, 2FKF, 2FKM, 2FUC, 2FUE, 2H4L, 2H5A, 2I54, 2I55, and 2Q4R.

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References
    • Small DM, Matheson NK (1979). "Phosphomannomutase and phosphoglucomutase in developing Cassia corymbosa seeds". Phytochemistry. 18 (7): 1147–1150. doi:10.1016/0031-9422(79)80123-5.


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