Phosphoenolpyruvate carboxykinase (diphosphate)

Phosphoenolpyruvate carboxykinase (diphosphate) (EC 4.1.1.38, phosphopyruvate carboxylase, phosphoenolpyruvate carboxylase, PEP carboxyphosphotransferase, PEP carboxykinase, phosphopyruvate carboxykinase (pyrophosphate), PEP carboxylase, phosphoenolpyruvic carboxykinase, phosphoenolpyruvic carboxylase, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxytransphosphorylase, phosphoenolpyruvate carboxykinase, phosphoenolpyruvic carboxykinase, PEPCTrP, phosphoenolpyruvic carboxykinase (pyrophosphate), phosphoenolpyruvic carboxylase (pyrophosphate), phosphoenolpyruvate carboxyphosphotransferase, phosphoenolpyruvic carboxytransphosphorylase, phosphoenolpyruvate carboxylase (pyrophosphate), phosphopyruvate carboxylase (pyrophosphate), diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)) is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming).[1] This enzyme catalyses the following chemical reaction

diphosphate + oxaloacetate phosphate + phosphoenolpyruvate + CO2
Phosphoenolpyruvate carboxykinase (diphosphate)
Identifiers
EC number4.1.1.38
CAS number2598306
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme also catalyses the reaction:

phosphoenolpyruvate + GTP + CO2 pyruvate + GDP.

It is transcriptionally upregulated in the liver by glucagon.

See also

References
  1. Lochmüller H, Wood HG, Davis JJ (December 1966). "Phosphoenolpyruvate carboxytransphosphorylase. II. Crystallization and properties". The Journal of Biological Chemistry. 241 (23): 5678–91. PMID 4288896.
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