Paraganglion

A paraganglion (pl. paraganglia) is a group of non-neuronal cells derived of the neural crest. They are named for being generally in close proximity to sympathetic ganglia. They are essentially of two types: (1) chromaffin or sympathetic paraganglia made of chromaffin cells and (2) nonchromaffin or parasympathetic ganglia made of glomus cells. They are neuroendocrine cells, the former with primary endocrine functions and the latter with primary chemoreceptor functions.[1]

Paraganglion
Paraganglion of gallbladder
Identifiers
THH3.08.02.8.00001
Anatomical terms of microanatomy

Chromaffin paraganglia (also called chromaffin bodies) are connected with the ganglia of the sympathetic trunk and the ganglia of the celiac, renal, adrenal, aortic and hypogastric plexuses. They are concentrated near the adrenal glands and essentially function the same way as the adrenal medulla. They are sometimes found in connection with the ganglia of other sympathetic plexuses. None have been found with the sympathetic ganglia associated with the branches of the trigeminal nerve. The largest chromaffin paraganglion is the organ of Zuckerkandl, it is probably the largest source of circulating catecholamines in the fetus and young infants, and gradually atrophies to microscopic loci.[1]

Nonchromaffin paraganglia include carotid bodies and aortic bodies, some are distributed in the ear, along the vagus nerve, in the larynx and at various other places.[2]

Clinical significance

Tumors of the paraganglionic tissues are known as paragangliomas, though this term tends to imply the nonchromaffin type, and can occur at a number of sites throughout the body.

Chromaffin paragangliomas are issued from chromaffin cells, and are known as pheochromocytomas. Adrenal pheochromocytomas are usually benign while extraadrenal ones are more malignant.[3] They are most of the time in the adrenals, and only rarely outside of the abdomen. They usually secrete hormones and estimates of a familial history vary.[1][2]

Nonchromaffin paragangliomas are issued from glomus cells, also known as glomus tumors. They are usually benign.[3] They are generally present at the head and neck, most often at carotid body or jugulo-tympanic, they rarely secrete hormones and commonly have a familial history.[1][2]

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References

This article incorporates text in the public domain from page 1277 of the 20th edition of Gray's Anatomy (1918)

  1. Anne Marie McNicol (2010). "Chapter 12: Adrenal medulla and paraganglia". Endocrine Pathology: Differential Diagnosis and Molecular Advance (Springer ed.). p. 281.
  2. WHO classification of tumors (2005). "Tumours of the Paraganglionic System". Pathology and genetics of head and neck tumours (PDF). Lyon: IARC Press. ISBN 9283224175.
  3. Klöppel, G (July 2003). "Tumors of the adrenal medulla and the paraganglia]". Der Pathologe. 24 (4): 280–6. doi:10.1007/s00292-003-0635-8. PMID 14513275.
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