Perfluorooctanoic acid

Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate)—also known as C8—is a perfluorinated carboxylic acid produced and used worldwide as an industrial surfactant in chemical processes and as a material feedstock, and is a health concern and subject to regulatory action and voluntary industrial phase-outs. PFOA is considered a surfactant, or fluorosurfactant, due to its chemical structure consisting of a perfluorinated, n-octyl "tail group" and a carboxylate "head group". The head group can be described as hydrophilic while the fluorocarbon tail is both hydrophobic and lipophobic. The tail group is inert and does not interact strongly with polar or non-polar chemical moieties; the head group is reactive and interacts strongly with polar groups, specifically water. The "tail" is hydrophobic due to being non-polar and lipophobic because fluorocarbons are less susceptible to the London dispersion force than hydrocarbons.[6]

Perfluorooctanoic acid
Names
IUPAC name
pentadecafluorooctanoic acid
Other names
perfluorooctanoic acid, PFOA, C8, perfluorooctanoate, perfluorocaprylic acid, FC-143, F-n-octanoic acid, PFO
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.817
EC Number
  • 206-397-9
RTECS number
  • RH0781000
UNII
Properties
C8HF15O2
Molar mass 414.07 g/mol
Appearance White solid
Density 1.8 g/cm3[1]
Melting point 40 to 50 °C (104 to 122 °F; 313 to 323 K)[1]
Boiling point 189 to 192 °C (372 to 378 °F; 462 to 465 K)[1]
soluble, 9.5 g/L (PFO)[2]
Solubility in other solvents polar organic
solvents
Acidity (pKa) ~0[3][4][5]
Hazards
Main hazards Strong acid and known carcinogen - also a persistent organic pollutant
Safety data sheet [1]
GHS pictograms
GHS Signal word Danger
GHS hazard statements
 H302, H318, H332, H351, H360, H362, H372
P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+312, P304+312, P304+340, P305+351+338, P308+313, P310, P312, P314, P330, P405, P501
NFPA 704 (fire diamond)
Flammability code 0: Will not burn. E.g. waterHealth code 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
0
3
0
Related compounds
Related compounds
 Perfluorooctanesulfonic acid (PFOS), Perfluorononanoic acid (PFNA), Perfluorooctanesulfonamide (PFOSA), Trifluoroacetic acid (TFA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

PFOA is used for several industrial applications, including carpeting, upholstery, apparel, floor wax, textiles, fire fighting foam and sealants. PFOA serves as a surfactant in the emulsion polymerization of fluoropolymers and as a building block for the synthesis of perfluoroalkyl-substituted compounds, polymers, and polymeric materials. PFOA has been manufactured since the 1940s in industrial quantities.[7] It is also formed by the degradation of precursors such as some fluorotelomers. PFOA is used as a surfactant because it can lower the surface tension of water more than hydrocarbon surfactants while having exceptional stability due to having perfluoroalkyl tail group.[6][8] The stability of PFOA is desired industrially but is a cause of concern environmentally.

A study of workers living near a DuPont Teflon plant found an association between PFOA exposure and two kinds of cancer as well as four other diseases. A positive exposure-response trend for kidney cancer is supported by many studies. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion (ppb) range, and levels are higher in chemical plant employees and surrounding subpopulations. How general populations are exposed to PFOA is not completely understood. PFOA has been detected in industrial waste, stain-resistant carpets, carpet-cleaning liquids, house dust, microwave popcorn bags, water, food, and Teflon (PTFE) products.

As a result of a class-action lawsuit and community settlement with DuPont, three epidemiologists conducted studies on the population surrounding a chemical plant that was exposed to PFOA at levels greater than in the general population. Studies have found correlation between high PFOA exposure and six health outcomes: kidney cancer, testicular cancer, ulcerative colitis, thyroid disease, hypercholesterolemia (high cholesterol), and pregnancy-induced hypertension.[9]

The primary manufacturer of PFOS, the 3M Company (known as Minnesota Mining and Manufacturing Company from 1902 to 2002), began a production phase-out in 2002 in response to concerns expressed by the United States Environmental Protection Agency (EPA).[10]:2 Eight other companies agreed to gradually phase out the manufacturing of the chemical by 2015.[10]:3

By 2014, EPA had listed PFOA and perfluorooctanesulfonates (salts of perfluorooctanesulfonic acid, PFOS) as emergent contaminants:

PFOA and PFOS are extremely persistent in the environment and resistant to typical environmental degradation processes. [They] are widely distributed across the higher trophic levels and are found in soil, air and groundwater at sites across the United States. The toxicity, mobility and bioaccumulation potential of PFOS and PFOA pose potential adverse effects for the environment and human health.[10]:1

History

3M (then Minnesota Mining and Manufacturing Company) began producing PFOA by electrochemical fluorination in 1947.[2] Starting in 1951, DuPont purchased PFOA from 3M for use in the manufacturing of specific fluoropolymers—commercially branded as Teflon, but DuPont internally referred to the material as C8.[11][12][13]

In 1968, organofluorine content was detected in the blood serum of consumers, and in 1976 it was suggested to be PFOA or a related compound such as PFOS.[14][15][16]

In 1999, EPA ordered companies to examine the effects of perfluorinated chemicals after receiving data on the global distribution and toxicity of PFOS.[17] For these reasons, and EPA pressure,[18] in May 2000, 3M announced the phaseout of the production of PFOA, PFOS, and PFOS-related products—the company's best-selling repellent.[19] 3M stated that they would have made the same decision regardless of EPA pressure.[20]

Because of the 3M phaseout, in 2002, DuPont built its own plant in Fayetteville, North Carolina to manufacture the chemical.[21] The chemical has received attention due to litigation from the PFOA-contaminated community around DuPont's Washington Works facility in Washington, West Virginia, along with EPA focus. In 2004, ChemRisk—an "industry risk assessor" that had been contracted by Dupont, reported that over 1.7 million pounds of C8 had been "dumped, poured and released" into the environment from Dupont's Parkersburg, West Virginia-based Washington Works plant between 1951 and 2003.[22]

Research on PFOA has demonstrated ubiquity, animal-based toxicity, and some associations with human health parameters and potential health effects. Additionally, advances in analytical chemistry in recent years have allowed the routine detection of low- and sub-parts per billion levels of PFOA in a variety of substances.[16] In 2013, Gore-Tex eliminated the use of PFOAs in the manufacture of its weatherproof functional fabrics.[23] Major companies producing PFOA signed with the Global PFOA Stewardship Program with the goal of elimination of PFOA by 2015.[24] Since then it has been eliminated from the production of non-stick used in cookware. GenX has been introduced as a replacement for PFOA, but in a 2015 study which tested the effects on rats, GenX caused many of the same health problems as PFOA, but required much higher concentrations, as GenX (C3) is a short chain alternative has a significantly shorter half-life (not as bio-persistent as PFOA or other long chain perfluorinated chemicals) .[25]

Rob Bilott investigation

In the fall of 2000, lawyer Rob Bilott, a partner at Taft Stettinius & Hollister, won a court order forcing DuPont to share all documentation related to PFOA. This included 110,000 files, consisting of confidential studies and reports conducted by DuPont scientists over decades. By 1993, DuPont understood that "PFOA caused cancerous testicular, pancreatic and liver tumors in lab animals" and the company began to investigate alternatives. However, products manufactured with PFOA were such an integral part of DuPont's earnings, $1 billion in annual profit, they chose to continue using PFOA.[11] Bilott learned that both "3M and DuPont had been conducting secret medical studies on PFOA for more than four decades", and by 1961 DuPont was aware of hepatomegaly in mice fed with PFOA.[11][26][27] Later research eventually found that PFOA had an outsized effect based on gender on several negative health outcomes in mice that had been exposed to the chemical. The PFOA exposure in these mice led to a modification of genetic expression. This led to the development of fatty tissue which caused the exposed mice to develop varying rates of hypercholesterolemia (high cholesterol). The impact of PFOA on this health outcome varied greatly between mice of different genotypes across relevant parts of the genome. Also, notably, female mice across all genotypes saw significantly higher rates and more severe cases of hypercholesterolemia.[28]

Bilott exposed how DuPont had been knowingly polluting water with PFOAs in Parkersburg, West Virginia since the 1980s.[11] In the 1980s and 1990s, researchers investigated the toxicity of PFOA.[27]

For his work in the exposure of the contamination, lawyer Rob Bilott has received several awards including The Right Livelihood Award in 2017.[29] This battle with DuPont is featured in the documentary The Devil We Know, which premiered at the Sundance Film Festival in 2018,[30] and Dark Waters, directed by Todd Haynes.

Synthesis

PFOA has two main synthesis routes, electrochemical fluorination (ECF) and telomerization.[2] The ECF route sees octanoyl chloride (the acid chloride of octanoic acid) reacted with hydrofluoric acid.[31] Multiple products are formed by ECF with the target acid fluoride F(CF2)7COF being produced as only 10–15% of the yield, while the main products are perfluorinated cyclic ether isomers, including FC-75.[31] This acid fluoride is hydrolyzed to yield PFOA as a mixture of straight-chain (78%), terminally branched (13%), and internally branched (9%) molecules, because ECF induces rearrangements the carbon tail of the acid chloride.[31] ECF also results in production wastes.[32] 3M synthesized ECF PFOA at their Cottage Grove, MN facility from 1947 to 2002 and was the world's largest producer.[2][32] ECF production continues on a smaller scale in Europe and Asia.[2]

PFOA is also synthesized by the telomerization represented below, where the telogen is the organoiodine compound and the taxogen is the tetrafluoroethylene.[31][33] Each step is an addition reaction where the carbon-iodine bond of the telogen is added across the carbon-carbon double bond of the unsaturated taxogen, resulting in the formation of a new telogen.

CF3CF2I + F2C=CF2 → CF3CF2CF2CF2I
CF3(CF2)3I + F2C=CF2 → CF3(CF2)5I
CF3(CF2)5I + F2C=CF2 → CF3(CF2)7I

The product is oxidized by SO3 to form PFOA.[31] Since each addition produces a new teleomer, fluorotelomers like these form with varying length chains containing an even number of carbon atoms, depending on reaction conditions. Typically, most products within will contain between two to six taxogens (that is, from CF3(CF2)5I to CF3(CF2)13I).[31] After oxidation, distillation is used to separate PFOA from the other perfluorinated carboxylic acids.[31] The telomerization synthesis of PFOA was pioneered by DuPont,[31] and is not well suited to the laboratory.[33] PFOA formed by telomerization is completely linear, in contrast to the mixture of structures formed by ECF.

Applications

PFOA has widespread applications. In 1976, PFOA was reported as a water and oil repellent "in fabrics and leather and in the production of floor waxes and waxed papers";[34] however, it is believed that paper is no longer treated with perfluorinated compounds, but with fluorotelomers with less than 0.1% PFOA.[35] The compound is also used in "insulators for electric wires, planar etching of fused silica",[33] fire fighting foam,[2][36] and outdoor clothing.[37] As a protonated species, the acid form of PFOA was the most widely used perfluorocarboxylic acid used as a reactive intermediate in the production of fluoroacrylic esters.[38][39]

ADONA, ammonium 4,8-dioxa-3H-perfluorononanoate, is 3M's PFOA replacement in the emulsion polymerization of fluoropolymers.[40]

As a salt, its dominant use is as an emulsifier for the emulsion polymerization of fluoropolymers such as PTFE, polyvinylidene fluoride, and fluoroelastomers.[41][42] For this use, 3M subsidiary Dyneon has a replacement emulsifer[43] despite DuPont stating PFOA is an "essential processing aid".[44] PFOA is used in the production of Gore-Tex[45] as it is PTFE-based. In PTFE processing, PFOA is in aqueous solution and forms micelles that contain tetrafluoroethylene and the growing polymer.[46] PFOA can be used to stabilize fluoropolymer and fluoroelastomer suspensions before further industrial processing and in ion-pair reversed-phase liquid chromatography it can act as an extraction agent.[47] PFOA also finds uses in electronic products and as an industrial fluorosurfactant.[45][8]

In a 2009 EPA study of 116 products, purchased between March 2007 and May 2008 and found to contain at least 0.01% fluorine by weight, the concentrations of PFOA were determined.[48] Concentrations shown below range from not detected, or ND, (with the detection limit in parenthesis) to 6750 with concentrations in nanograms of PFOA per gram of sample (parts per billion) unless stated otherwise.

Science is still evolving to understand the fate, exposure, and toxicity of PFAS (per- and polyfluoroalkyl substances, of which PFOA is a subtype) in various environmental media. The analytical methods needed to study and accurately monitor these chemicals at such trace concentrations are still in development for media other than drinking water. In addition, the extent of public health impacts remains unclear and is not fully understood. [49]

Product Range, ng/g
Pre-treated carpetingND (<1.5) to 462
Carpet-care liquids19 to 6750
Treated apparel5.4 to 161
Treated upholstery0.6 to 293
Treated home textiles3.8 to 438
Treated non-woven medical garments46 to 369
Industrial floor wax and wax removers7.5 to 44.8
Stone, tile, and wood sealants477 to 3720
Membranes for apparel0.1 to 2.5 ng/cm2
Food contact paperND (<1.5) to 4640
Dental floss/tapeND (<1.5) to 96.7
Thread sealant tapeND (<1.5) to 3490
PTFE cookwareND (<1.5) to 4.3

Global occurrence and sources

PFOA contaminates every continent.[50] Two of the most common types (PFOS and PFOA) were phased out of production in the United States (US) in 2002 and 2015 respectively, but are still present in some imported products. PFOA and PFOS are found in every American person’s blood stream in the parts per billion range, though those concentrations have decreased by 70% for PFOA and 84% for PFOS between 1999 and 2014, which coincides with the end of the production and phase out of PFOA and PFOS in the US2.[51] PFOA has been detected in the central Pacific Ocean at low parts per quadrillion ranges, and at low parts per trillion (ppt) levels in coastal waters.[52] Due to the surfactant nature of PFOA, it has been found to concentrate in the top layers of ocean water.[53] PFOA is detected widely in surface waters, and is present in numerous mammals, fish, and bird species.[50] PFOA is in the blood or vital organs of Atlantic salmon, swordfish, striped mullet, gray seals, common cormorants, Alaskan polar bears, brown pelicans, sea turtles, sea eagles, Midwestern bald eagles, California sea lions and Laysan albatrosses on Sand Island, a wildlife refuge on Midway Atoll, in the middle of the North Pacific Ocean, about halfway between North America and Asia.[11] Because PFAS are ubiquitous in households, consumer products, food, and the environment generally, some trace levels reflecting this ubiquitous broad use of these compounds will make their way into the wastewater and solid waste streams. [54]

However, wildlife has much less PFOA than humans, unlike PFOS[55] and other longer perfluorinated carboxylic acids;[56] in wildlife, PFOA is not as bioaccumulative as longer perfluorinated carboxylic acids.[57] Municipal wastewater and landfill leachates are considered as important sources of PFOA to the environment,[58][59]

Most industrialized nations have average PFOA blood serum levels ranging from 2 to 8 parts per billion;[60] the highest consumer sub-population identified was in Korea—with about 60 parts per billion.[55] In Peru,[61] Vietnam,[62] and Afghanistan[63] blood serum levels have been recorded to be below one part per billion. In 2003–2004 99.7% of Americans had detectable PFOA in their serum with an average of about 4 parts per billion,[64] and concentrations of PFOA in US serum have declined by 25% in recent years.[65] Despite a decrease in PFOA, the longer perfluorinated carboxylic acid PFNA is increasing in the blood of US consumers.[64] PFAS are also found in paper mill residuals, digestates, composts, and soils. Given the ubiquity of PFAS, and the comparative background levels which may be found in wastewater, biosolids, and leachates, setting requirements near analytical detection limits on these sources may not provide a discernable benefit to protecting public health. [66]

Industrial sources

PFOA is released directly from industrial sites. For example, the estimate for the DuPont Washington Works facility is a total PFOA emissions of 80,000 pounds (lbs) in 2000 and 1,700 pounds in 2004.[12] A 2006 study, with two of four authors being DuPont employees, estimated about 80% of historical perfluorocarboxylate emissions were released to the environment from fluoropolymer manufacture and use.[2] PFOA can be measured in water from industrial sites other than fluorochemical plants. PFOA has also been detected in emissions from the carpet industry,[67] paper[68] and electronics industries.[69] The most important emission sources are carpet and textile protection products, as well as fire-fighting foams.[70]

Precursors
8:2 fluorotelomer alcohol, (8:2 FTOH), degrades environmentally to PFOA

PFOA can form as a breakdown product from a variety of precursor molecules. In fact, the main products of the fluorotelomer industry, fluorotelomer-based polymers, have been shown to degrade to form PFOA and related compounds, with half-lives of decades, both biotically[71] and by simple abiotic reaction with water.[72] It has been argued that fluorotelomer-based polymers already produced might be major sources of PFOA globally for decades to come.[72] Other precursors that degrade to PFOA include 8:2 fluorotelomer alcohol (F(CF2)8CH2CH2OH), polyfluoroalkyl phosphate surfactants (PAPS),[73] and possibly N-EtFOSE alcohol (F(CF2)8SO2N(Et)CH2CH2OH).[50][74] When PTFE (Teflon) is degraded by heat (pyrolysis) it can form PFOA as a minor product.[75][76] The Organisation for Economic Co-operation and Development (OECD) has compiled a list of 615 chemicals that have the potential to break down into perfluorocarboxylic acids (PFCA) including PFOA.[77] However, not all 615 have the potential to break down to form PFOA.

A majority of waste water treatment plants (WWTPs) that have been tested output more PFOA than is input, and this increased output has been attributed to the biodegradation of fluorotelomer alcohols.[78] A current PFOA precursor concern are fluorotelomer-based polymers; fluorotelomer alcohols attached to hydrocarbon backbones via ester linkages may detach and be free to biodegrade to PFOA.[79]

Sources to people

Food,[80] drinking water,[81] outdoor air, indoor air,[82] dust, and food packagings[83] are all implicated as sources of PFOA to people.[73] However, it is unclear which exposure routes dominate[84] because of data gaps. When water is a source, blood levels are approximately 100 times higher than drinking water levels.[85][86]

People who lived in the PFOA-contaminated area around DuPont's Washington Works facility were found to have higher levels of PFOA in their blood from drinking water. The highest PFOA levels in drinking water were found in the Little Hocking water system, with an average concentration of 3.55 parts per billion during 2002–2005.[12] Individuals who drank more tap water, ate locally grown fruits and vegetables, or ate local meat, were all associated with having higher PFOA levels. Residents who used water carbon filter systems had lower PFOA levels.

Food contact surfaces
Microwave popcorn bags can contain residual PFOA from fluorotelomers

PFOA is also formed as an unintended byproduct in the production of fluorotelomers[87] and is present in finished goods treated with fluorotelomers, including those intended for food contact. Fluorotelomers are applied to food contact papers because they are lipophobic: they prevent oil from soaking into the paper from fatty foods. Also, fluorotelomers can be metabolized into PFOA.[88] In a U.S. Food and Drug Administration (USFDA) study, lipophobic fluorotelomer-based paper coatings (which can be applied to food contact paper in the concentration range of 0.4%) were found to contain 88,000–160,000 parts per billion PFOA before application, while the oil from microwave popcorn bags contained 6–290 parts per billion PFOA after heating.[89] Toxicologists estimate that microwave popcorn could account for about 20% of the PFOA levels measured in an individual consuming 10 bags a year if 1% of the fluorotelomers are metabolized to PFOA.[88]

In 2008 as news stories began to raise concerns about PFOA in microwaved popcorn, Dan Turner, DuPont's global public relations chief, said, "I serve microwave popcorn to my three-year-old." Five years later, journalist Peter Laufer wrote to Turner to ask if his child was still eating microwave popcorn. "I am not going to comment on such a personal inquiry", Turner replied.[90][91]

Fluorotelomer coatings are used in fast food wrappers, candy wrappers, and pizza box liners.[92] PAPS, a type of paper fluorotelomer coating, and PFOA precursor, is also used in food contact papers.[73]

Despite DuPont's asserting that "cookware coated with DuPont Teflon non-stick coatings does not contain PFOA",[93] residual PFOA was also detected in finished PTFE products including PTFE cookware (4–75 parts per billion).[89] However, PFOA levels ranged from undetectable (<1.5) to 4.3 parts per billion in a more recent study.[48] Also, non-stick cookware is heated—which should volatilize PFOA; PTFE products that are not heated, such as PTFE sealant tape, had higher (1800 parts per billion) levels detected.[94] Overall, PTFE cookware is considered an insignificant exposure pathway to PFOA.[95][96]

Potential path: sludge to food

PFOA and PFOS were detected in "very high" (low parts per million) levels in agricultural fields for grazing beef cattle[84] and crops[97] around Decatur, AL.[98] The approximately 5000 acres of land were fertilized with "treated municipal sewage sludge, or biosolids".[84] PFOA was also detected in fodder grass grown in these soils[99] and the blood of the cattle feeding on this grass.[100] The water treatment plant received process wastewater from a nearby perfluorochemical manufacturing plant. 3M says they managed their own wastes, but Daikin America "discharged process wastewater to the municipal waste treatment plant".[84] If traced to meat, it would be the first time perfluorochemicals were traced from sludge to food.[84] However, the USDA reported—with a detection limits of 20 parts per billion—non-detectable levels for both PFOA and PFOS in cattle muscle tissue.[101]

Household dust

PFOA is frequently found in household dust, making it an important exposure route for adults, but more substantially, children. Children have higher exposures to PFOA through dust compared to adults.[102] Hand-to-mouth contact and proximity to high concentrations of dust make them more susceptible to ingestion, and increases PFOA exposure.[103] One study showed significant positive associations were recognized between dust ingestion and PFOA serum concentrations.[102] However, an alternate study found exposure due to dust ingestion was associated with minimal risk.[104]

Regulatory status

Drinking water and products

In the United States there are no federal drinking water standards for PFOA or PFOS as of early 2020. EPA began requiring public water systems to monitor for PFOA and PFOS in 2012,[105] and published drinking water health advisories, which are non-regulatory technical documents, in 2016. The lifetime health advisories and health effects support documents assist federal, state, tribal, and local officials and managers of drinking water systems in protecting public health when these chemicals are present in drinking water. The levels of PFOS and PFOA concentrations under which adverse health effects are not anticipated to occur over a lifetime of exposure are 0.07 ppb (70 ppt).[106] EPA is considering developing a National Primary Drinking Water Regulation for these contaminants.[107]

In November 2017 the State of New Jersey announced plans to develop its own drinking water standards for PFOA and PFNA.[108]

In 2018 the State of New York adopted drinking water standards of 10 ppt for PFOA and 10 ppt for PFOS, the most stringent such standards in the United States. The standards apply to public water systems and took effect in 2019 after a public comment period.[109]

Using information gained through a Freedom of Information Act request, in May 2018 it was learned that January 2018 emails between the EPA, the Office of Management and Budget, the Department of Defense, and the Department of Health and Human Services showed an effort to suppress the release of a draft report on the toxicology of PFOS and PFOA done by the Agency for Toxic Substances and Disease Registry. The report found that these chemicals endanger human health at a far lower level than EPA has previously called safe.[110] After media accounts of the effort surfaced, the regional EPA administrator for Colorado denied that EPA had anything to do with suppressing the report.[111] The report was finally released on June 21, 2018.[81]

The new ATSDR analysis derives provisional Minimal Risk Levels (MRLs) of 3x10−6 mg/kg/day for PFOA and 2x10−6 mg/kg/day for PFOS during intermediate exposure.[112] The European Food Safety Authority opinion sets a provisional tolerable weekly intake (TWI) of 6 x10−6 mg/kg body weight per week for PFOA.[113]

California and food packaging

An attempt to regulate PFOA in food packaging occurred in the US state of California in 2008. A bill, sponsored by State Senator Ellen Corbett and the Environmental Working Group, was passed in the house and senate that would have banned PFOA, PFOS, and seven or more related fluorinated carbon compounds in food packaging starting in 2010,[114][115] but the bill was vetoed by Governor Schwarzenegger.[116] The bill would have affected fluorochemical manufacturers outside of the state. Schwarzenegger said the compound should be reviewed by the newly established, and more comprehensive, state program.[116]

Fluorotelomers
Main article: Fluorotelomer

Fluorotelomer-based products have been shown to degrade to PFOA over periods of decades;[71] [72] these studies could lead EPA to require DuPont and others to reformulate products with a value over $1 billion.[117]

Health concerns

Toxicology data

PFOA is a carcinogen, a liver toxicant, a developmental toxicant, and an immune system toxicant, and also exerts hormonal effects including alteration of thyroid hormone levels.[42] Animal studies show developmental toxicity from reduced birth size, physical developmental delays, endocrine disruption, and neonatal mortality.[50][118] PFOA alters lipid metabolism.[50] It is an agonist of PPARα and is a peroxisome proliferator in rodents contributing to a well understood form of oxidative stress.[119] Humans are considered less susceptible to peroxisome proliferation than rodents. However, PFOA has been found to be a liver carcinogen in rainbow trout via a potential estrogenic mechanism, which may be more relevant to humans.[119]

An EPA review notes that PFOA has not "been shown to be mutagenic in a variety of assays".[42] PFOA has been described as a member of a group of "classic non-genotoxic carcinogens".[120] However, a provisional German assessment notes that a 2005 study found PFOA to be genotoxic via a peroxisome proliferation pathway that produced oxygen radicals in HepG2 cells, and a 2006 study demonstrated the induction and suppression of a broad range of genes; therefore, it states that the indirect genotoxic (and thus carcinogenic) potential of PFOA cannot be dismissed.[121] Criteria have been proposed that would allow PFOA, and other perfluorinated compounds, to be classified as "weakly non-specific genotoxic".[122]

Endocrine Disruption of Sexual Steroids

In 2018, an in vitro toxicology study analyzed the disruptor effect of PFOS and PFOA on porcine ovarian cell steroidogenesis. Specifically, the study focused on secretion in porcine theca and granulosa cells, controlling gonadotropic stimulation. PFOS and PFOA chemicals were used from Sigma-Aldrich Co. (St. Louis, MO, USA). Five ovaries were obtained and dissected to collect theca and granulosa cells.[123]

The experimental design included: evaluation of PFOS & PFOA on basal steroid secretion, stimulation of LH on theca cells and FSH on granulosa cells, effect of PFOS & PFOA on steroidogenesis in the stimulated cells, quantification of steroid hormones by chemiluminescence, protein content determination, statistical analysis.[123]

The treatment groups had 9 data points each, from which the mean and standard deviation were calculated. The control group had 15 data points. A multi-factor analysis of variance (ANOVA)  and Tukey’s test were used for the concentrations of P4, A4 and E2. The two groups were compared using a Student’s “t”, with statistical significance set at p < 0.05.[123]

Results show the disruptor effect of PFOS and PFOA depends on cell type. PFOS and PFOA inhibit the secretion of steroid hormones in both theca cells and granulosa cells with gonadotropic stimulus. In cells without gonadotropic stimulus, PFOS inhibit theca cells but not granulosa, while PFOA inhibit granulosa cells but not theca. These differences are explained by the different types of PPARs  in cell type. The study used concentrations below the range found in human blood circulation, suggesting that this may occur in human population. These results indicated PFOS and PFOA act as endocrine disruptors on ovarian cells which could affect subsequent sexual steroids.[123]

Human data

PFOA is resistant to degradation by natural processes such as metabolism, hydrolysis, photolysis, or biodegradation[38] and has been found to persist in the environment.[84] PFOA is found in environmental and biological fluids as the anion perfluorooctanoate.[124] PFOA can be absorbed from ingestion and can penetrate skin.[14] The acid headgroup of PFOA enables binding to proteins with fatty acid or hormone substrates such as serum albumin, liver fatty acid-binding protein, and the nuclear receptors PPARα[42] and possibly CAR.[125]

In animals, PFOA is mainly present in the liver, blood, and kidneys.[14] PFOA does not accumulate in fat tissue, unlike traditional organohalogen persistent organic pollutants.[57] In humans, PFOA has an average elimination half-life of about 3 years.[126][127][128] Because of this long half-life,[129] PFOA has the potential to bioaccumulate.

The levels of PFOA exposure in humans vary widely. While an average American might have 3 or 4 parts per billion of PFOA present in their blood serum,[130] individuals occupationally exposed to PFOA have had blood serum levels over 100,000 parts per billion (100 parts per million or 0.01%) recorded.[131] In a study of individuals living around DuPont's Washington Works plant, those who had no occupational exposure had a median blood serum level of 329 parts per billion while the median of those with occupational exposure was 775 parts per billion.[12] While no amount of PFOA in humans is legally recognized as harmful, DuPont was "not satisfied" with data showing their Chinese workers accumulated an average of about 2,250 parts per billion of PFOA in their blood from a starting average of around 50 parts per billion less than a year prior.[21]

In late 2012, scientists at Emory University compared health risks in workers at a DuPont chemical plant in West Virginia with high PFOA exposure to the risks of the same diseases in other regional DuPont factory workers and in the US population. In comparison with the other DuPont workers, workers at the high-PFOA plant were at roughly three times the risk of dying of mesothelioma or chronic kidney disease, and roughly twice the risk of dying of diabetes mellitus. Workers were at similarly elevated risk for kidney cancer and for non-cancer kidney diseases. In rodents, PFOA concentrates in the kidneys.[132]

Consumers

Single cross-sectional studies on consumers have been published noting multiple associations. Blood serum levels of PFOA were associated with an increased time to pregnancy—or "infertility"—in a 2009 study.[133] PFOA exposure was associated with decreased semen quality,[134] increased serum alanine aminotransferase levels,[135] and increased occurrence of thyroid disease.[129] In a study of 2003–2004 US samples, a higher (9.8 milligram per deciliter) total cholesterol level was observed when the highest quartile was compared to the lowest.[136] Along with other related compounds, PFOA exposure was associated with an increased risk of attention deficit hyperactivity disorder (ADHD) in a study of US children aged 12–15.[137] In a paper presented at the 2009 annual meeting of the International Society of Environmental Epidemiology,[138] PFOA appeared to act as an endocrine disruptor by a potential mechanism on breast maturation in young girls.[139] A C8 Science Panel status report noted an association between exposure in girls and a later onset of puberty.[140]

PFOA Exposure and Incident Cancer Research

Extensive research on PFOA and its role in the causal pathway of cancers exists for animals, however human studies are rare—most studies are mortality studies, which have small sample sizes.  A longitudinal study focused on residents living in Mid-Ohio Valley concluded that PFOA concentrations are positively associated with kidney and testicular cancers [hazard ratio = 1.10 and 1.34, respectively, for a 1-unit increase in log-transformed serum PFOA]. The study consisted of 32,254 residents with 2,507 reported cancer diagnoses occurring during study period. PFOA serum concentrations were measured at baseline and three to six year follow-up meetings. Retrospective yearly PFOA serum levels were estimated for each subject from 1952 through 2011.[141]

Initial subject recruitment was performed using eligibility criteria and surveys—subjects were eligible if they lived or worked in one of the six contaminated water districts for at least one year between 1950 and December 3, 2004. Follow-up surveys were administered and remaining subjects (completion of at least one survey) were then included in the analysis dataset—selection bias was assessed and the final subjects did not differ significantly from the original population.[141]

Retrospective PFOA serum concentrations were calculated using the published method of Shin et al. 2011a, 2011b). Historical regional data including emission rates by the DuPont facility, temporal patterns and groundwater flow are incorporated in the model as well as individual  specific occupational exposure level was included. A job-exposure matrix was developed to assess estimated PFOA levels for workers across times and job roles.[141]

Incident data was self-reported by study participants and followed up with a medical chart review. Cancer diagnoses were verified using Ohio/West Virginia cancer registries.[141]

A proportional hazards regression model was used for each cancer type with the cancer as the outcome and PFOA serum level included as a time-varying covariate. Participants were followed from age 20 (or age in 1952) to the age of cancer diagnosis. Models were adjusted for time-varying- smoking and alcohol consumption, as well as sex, education and 5-year birth cohort. The outcome of PFOA serum level was log-transformed due to the scarcity of very high cumulative exposure values.[141]

Participants who worked at the DuPont facility had higher PFOA serum levels and higher estimated annual PFOA levels than subjects who never worked at the facility. After cancer diagnosis validation, thyroid, kidney and testicular cancer risk were found to increase with an increase in the PFOA serum concentration (log-transformed), with testicular cancer being significantly associated (α =0.05). The results are consistent with previous mortality analyses performed using DuPont data. There is a positive exposure-response trend for cancer incidence and PFOA serum levels. Kidney and testicular cancer are of interest given that animal studies have found that PFOA is distributed mainly in the kidneys and because PFOA has been found to induce testicular tumors in rats.[141]

Impact of In Utero Exposure on Reproductive Organs

Due to the fact that PFOA is able to readily pass through the placental barrier, exposure is of particular concern during in utero development.[142] Numerous studies have analyzed the impacts of PFOA on fetal development of reproductive organs. One study that followed a Danish pregnancy cohort suggests that in utero exposure to PFOA could be associated with lower levels of sperm concentration and total sperm count in adult males, reduced testicular size, and higher adjusted levels of luteinizing hormone and follicle-stimulating hormone.[142] In utero PFOA exposure is also demonstrated to impact female development. For example, a study following a Danish population-based cohort found a 5.3 month later age of menarche in girls exposed to higher levels of PFOA in utero. Delayed onset of menarche is associated with lower bone mineral density and may have psychosocial impacts.[143]

Other Impacts on Exposure In Utero

PFOA exposure on thyroid function has also been a topic of concern, and has found to negatively impact thyroid stimulating hormone even at low levels when exposed during fetal development.[144] PFOA is also shown to have obesogenic effects, and an experimental study found a positive correlation to low-dose prenatal exposure of PFOA and prevalence of overweight and high waist circumference in females at age 20.[145] A correlation between in utero PFOA exposure and mental performance has yet to be established, as many studies have resulted in insignificant results. For example, a study conducted near Parkersburg, West Virginia did not find a significant association between in utero PFOA exposure and performance of math skills or reading performance in children ages 6 to 12 living in the PFOA-contaminated water district.[146] Based on a cohort study conducted in the Mid-Ohio Valley, no clear association was found between prenatal exposure to PFOA and birth defects, although a possible association with brain defects was observed and requires further research and assessment.[147]

PFOA has been associated with signs of reduced fetal growth including lower birth weight.[148][149][150] However, other studies have not replicated the lower birth weight finding[151][152] including a study on the DuPont exposed community.[153] Extrapolated epidemiological data suggests a slight association between PFOA exposure and low birth weight.[154] This was consistent based on blood levels of PFOA metabolites regardless of the geographic residence of subjects.[154] Generally, the findings among human fetuses exposed to the chemical were considerably less drastic than what was seen in mice studies.[154] Because of this, studies linking exposure to low birth weight can be considered inconclusive.[154] PFOA exposure in the Danish general population was not associated with an increased risk of prostate, bladder, pancreatic, or liver cancer.[155] Maternal PFOA levels were not associated with an offspring's increased risk of hospitalization due to infectious diseases,[156] behavioral and motor coordination problems,[157] or delays in reaching developmental milestones.[158]

Employees and DuPont exposed community

In 2010, the three members of the C8 Science Panel[159] published a review of the epidemiological evidence on PFOA exposure in Environmental Health Perspectives.[127] Insufficient evidence exists to conclude PFOA causes adverse health effects in humans, but consistent evidence exists on associations with higher cholesterol and uric acid. Whether or not these potential effects result in an increase in cardiovascular disease is unknown.[160] Further data on the 69,030 member cohort[161] that is being studied by the panel is scheduled for release through 2012.[162] A 2011 epidemiological study demonstrated "probable link" between PFOA and kidney cancer, testicular cancer, thyroid disease, high cholesterol, pre-eclampsia and ulcerative colitis.[11][163]

Facial birth defects, an effect observed in rat offspring, occurred with the children of two out of seven female DuPont employees from the Washington Works facility from 1979 to 1981.[27][164] Bucky Bailey is one of the affected individuals; DuPont, however, does not accept any liability from the toxicity of PFOA.[165] While 3M sent DuPont results from a study that showed birth defects to rats administered PFOA and DuPont moved the women out of the Teflon production unit,[27] subsequent animal testing led DuPont to conclude there was no reproductive risk to women, and they were returned to the production unit.[166] However, data released in March 2009 on the community around DuPont's Washington Works plant showed "a modest, imprecise indication of an elevation in risk ... above the 90th percentile ... based on 12 cases in the uppermost category", which was deemed "suggestive of a possible relationship" between PFOA exposure and birth defects.[167][168]

PFOA was proposed for listing under the Stockholm Convention on Persistent Organic Pollutants in 2015, and on May 10, 2019, PFOA, its salts, and PFOA-related compounds were added to Annex A of the Stockholm Convention by the Conference of the Parties.[169][170]

DuPont has used PFOA for over 50 years at its Washington Works plant. Area residents sued DuPont in August 2001 and claimed DuPont released PFOA in excess of their community guideline of 1 part per billion resulting in lower property values and increased risk of illness.[27] The class was certified by Wood Circuit Court Judge George W. Hill.[171] As part of the settlement, DuPont has paid for blood tests and health surveys of residents believed to be affected.[172] Participants numbered 69,030 in the study, which was reviewed by three epidemiologists—the C8 Science Panel—to determine if any health effects are the likely result of exposure.

On December 13, 2005, DuPont announced a settlement with the EPA in which DuPont would pay US$10.25 million in fines and an additional US$6.25 million for two supplemental environmental projects without any admission of liability.[173]

On September 30, 2008, Chief Judge Joseph R. Goodwin of the United States District Court for the Southern District of West Virginia denied the certification of a class of Parkersburg residents exposed to PFOA from DuPont's facility because they did not "show the common individual injuries needed to certify a class action".[174] On September 28, 2009, Judge Goodwin dismissed the claims of those residents except for medical monitoring.[171][175] By 2015, more than three thousand plaintiffs have filed personal-injury lawsuits against DuPont.[11] In 2017, DuPont reached a $670.7 million cash settlement[176] related to 3,550 personal injury lawsuits tied to PFOA contamination of drinking water in the Parkersburg area. Chemours, which was spun off from DuPont in 2015, agreed to pay half the settlement. Both companies denied any wrongdoing.

U.S. federal government actions

In 2002, a panel of toxicologists, including several from EPA, proposed a level of 150 ppb for drinking water in the PFOA contaminated area around DuPont's Washington Works plant. This initially proposed level was much higher than any known environmental concentration[45] and was over 2,000 times the level EPA eventually settled on for the drinking water health advisory.

In July 2004, EPA filed a suit against DuPont alleging "widespread contamination" of PFOA near the Parkersburg, West Virginia plant "at levels exceeding the company's community exposure guidelines;" the suit also alleged that "DuPont had—over a 20 year period—repeatedly failed to submit information on adverse effects (in particular, information on liver enzyme alterations and birth defects in offspring of female Parkersburg workers)."[27]

In October 2005, a USFDA study was published revealing PFOA and PFOA precursor chemicals in food contact and PTFE products.[89]

On January 25, 2006, EPA announced a voluntary program with several chemical companies to reduce PFOA and PFOA precursor emissions by the year 2015.[177]

On February 15, 2005, EPA's Science Advisory Board (SAB) voted to recommended that PFOA should be considered a "likely human carcinogen".[178]

On May 26, 2006, EPA's SAB addressed a letter to Administrator Stephen L. Johnson. Three-quarters of advisers thought the stronger "likely to be carcinogenic" descriptor was warranted, in opposition to EPA's own PFOA hazard descriptor of "suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential".[179]

On November 21, 2006, EPA ordered DuPont to offer alternative drinking water or treatment for public or private water users living near DuPont's Washington Works plant in West Virginia (and in Ohio), if the level of PFOA detected in drinking water is equal to or greater than 0.5 parts per billion. This measure sharply lowered the previous action level of 150 parts per billion that was established in March 2002.[180]

According to a May 23, 2007, Environmental Science & Technology Online article, U.S. Food and Drug Administration research regarding food contact papers as a potential source of PFOA to humans is ongoing.[73]

In November 2007, the Centers for Disease Control and Prevention (CDC) published data on PFOA concentrations comparing 1999–2000 vs. 2003–2004 NHANES samples.[64]

On January 15, 2009, EPA set a provisional health advisory level of 0.4 ppb in drinking water.[100]

On May 19, 2016, EPA lowered the drinking water health advisory level to 0.07 ppb for PFOA and PFOS.[181]

In March 2020 EPA published a Federal Register notice requesting public comment on whether it should set drinking water standards for PFOA and PFOS in public water systems.[107]

U.S. state government actions

In 2007, the New Jersey Department of Environmental Protection (NJDEP) issued a preliminary health-based guidance level of 0.04 ppb in drinking water, due to PFOA being found at "elevated levels in the system's drinking water near DuPont's massive Chambers Works chemical plant".[182] In November 2017 NJDEP announced plans to develop regulatory drinking water standards for PFOA and PFNA, in the absence of federal standards.[108]

In 2007, the Minnesota Department of Health lowered its Health Based Value for PFOA in drinking water from 1.0 ppb to 0.5 ppb,[183] where "the sources are landfilled industrial wastes from a 3M manufacturing plant".[182]

In 2018 the New York State Department of Health adopted drinking water standards of 10 ppt for PFOA and 10 ppt for PFOS, effective in 2019 after a public comment period.[109]

United Nation action

The United Nation’s Stockholm Convention’s Persistent Organic Pollutants Review Committee (POPRC) recommended to eliminate PFOA, its salts, and PFOA-related compounds in September 2018. This decision was made by over 150 chemical experts from all UN regions. The committee and scientist stated there was enough evidence to link the chemical with negative environmental and human health outcomes to pave the way for a global ban of PFOA use. This recommendation will be reviewed in April–May, 2019, at the Conference of the Parties (COP) meeting in Geneva.[184]

European action

PFOA contaminated waste was incorporated into soil improver and spread on agricultural land in Germany, leading to PFOA drinking water contamination of up to 0.519 parts per billion.[185][186] The German Federal Environmental Agency issued guidelines for the sum of PFOA and PFOS concentrations in drinking water: 0.1 parts per billion for precaution and 0.3 parts per billion for a threshold.[122] Residents were found to have a 6–8 factor increase of PFOA serum levels over unexposed Germans, with average PFOA concentrations in the 22–27 parts per billion range.[50] An expert panel concluded that "concentrations were considered too low to cause overt adverse health effects in the exposed population".[122]

In the Netherlands, after questions by members of Parliament, the minister of Environment ordered a study into the potential exposure to PFOA of people living in the vicinity of the DuPont factory in Dordrecht. The report was published in March 2016 and concluded that "prior to 2002 residents were exposed to levels of PFOA at which health effects could not be ruled out".[187] As a result of this, the government commissioned several further studies, including blood tests and measurements in drinking water.

PFOA was identified as a PBT substance in the EU in 2013. It was then included in the candidate list of substances of very high concern. In 2017, PFOA, its salts and PFOA-related substances were added to annex XVII (restriction) of the REACH Regulation.[188]

Australian action

On August 10, 2016, Australian litigation funder IMF Bentham announced an agreement to fund a class action led by the law firm Gadens against the Australian Department of Defence for economic losses to homeowners, fishers, and farmers resulting from the use of aqueous film forming foam (containing PFOA) at RAAF Base Williamtown.[189]

gollark: Plethora maybe?
gollark: Dan200 === bees
gollark: ···
gollark: Oh no. How terrible?
gollark: Because it would be useful? The mod is kind of irritating generally though, the docs are... not good.

See also
  • Perfluorinated alkylated substances (PFAS)
  • Pollution of the Ohio River
  • Timeline of events related to per- and polyfluoroalkyl substances (PFAS)
  • Weinberg Group

References
  1. Record of Perfluorooctanoic acid in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 5 November 2008.
  2. Prevedouros K, Cousins IT, Buck RC, Korzeniowski SH (January 2006). "Sources, fate and transport of perfluorocarboxylates". Environ. Sci. Technol. 40 (1): 32–44. Bibcode:2006EnST...40...32P. doi:10.1021/es0512475. PMID 16433330.
  3. Goss K. U. (July 2008). "The pKa values of PFOA and other highly fluorinated carboxylic acids". Environ. Sci. Technol. 42 (2): 456–458. Bibcode:2008EnST...42..456G. doi:10.1021/es702192c. PMID 18284146.
  4. Cheng J, Psillakis E, Hoffmann MR, Colussi AJ (July 2009). "Acid dissociation versus molecular association of perfluoroalkyl oxoacids: Environmental implications". J. Phys. Chem. A. 113 (29): 8152–8156. Bibcode:2009JPCA..113.8152C. doi:10.1021/jp9051352. PMID 19569653.
  5. Rayne S, Forest K (June 2010). "Theoretical studies on the pKa values of perfluoroalkyl carboxylic acids". J. Mol. Struct. (Theochem). 949 (1–3): 60–69. doi:10.1016/j.theochem.2010.03.003.
  6. Lemal DM (January 2004). "Perspective on fluorocarbon chemistry". J. Org. Chem. 69 (1): 1–11. doi:10.1021/jo0302556. PMID 14703372.
  7. Lindstrom, Andrew B.; Strynar, Mark J.; Libelo, E. Laurence (2011-08-25). "Polyfluorinated Compounds: Past, Present, and Future". Environ. Sci. Technol. 45 (19): 7954–7961. Bibcode:2011EnST...45.7954L. doi:10.1021/es2011622. PMID 21866930.
  8. Salager, Jean-Louis (2002). FIRP Booklet # 300-A: Surfactants-Types and Uses (PDF). Universidad de los Andes Laboratory of Formulation, Interfaces Rheology, and Processes. p. 44. Retrieved 2008-09-07.
  9. Nicole, W. (2013). "PFOA and Cancer in a Highly Exposed Community: New Findings from the C8 Science Panel". Environmental Health Perspectives. 121 (11–12): A340. doi:10.1289/ehp.121-A340. PMC 3855507. PMID 24284021.
  10. Emerging Contaminants Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) (Report). EPA. March 2014. 505-F-14-001. Fact sheet.
  11. Rich, Nathaniel (6 January 2016). "The Lawyer Who Became DuPont's Worst Nightmare". New York Times. Retrieved 8 January 2016.
  12. Emmett EA, Shofer FS, Zhang H, Freeman D, Desai C, Shaw LM (August 2006). "Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources". J. Occup. Environ. Med. 48 (8): 759–70. doi:10.1097/01.jom.0000232486.07658.74. PMC 3038253. PMID 16902368.
  13. "Perfluorooctanoic acid". National Center for Biotechnology Information. PubChem. Retrieved 2019-09-30.
  14. Kennedy GL, Butenhoff JL, Olsen GW, et al. (2004). "The toxicology of perfluorooctanoate". Crit. Rev. Toxicol. 34 (4): 351–84. doi:10.1080/10408440490464705. PMID 15328768.
  15. Giesy JP, Kannan K (April 2002). "Perfluorochemical surfactants in the environment". Environ. Sci. Technol. 36 (7): 146A–152A. Bibcode:2002EnST...36..146G. doi:10.1021/es022253t. PMID 11999053.
  16. Lau C, Butenhoff JL, Rogers JM (July 2004). "The developmental toxicity of perfluoroalkyl acids and their derivatives". Toxicol. Appl. Pharmacol. 198 (2): 231–41. doi:10.1016/j.taap.2003.11.031. PMID 15236955.
  17. Ullah, Aziz (October 2006). "The Fluorochemical Dilemma: What the PFOS/PFOA fuss is all about" (PDF). Cleaning & Restoration. Retrieved 2008-09-24.
  18. Lee, Jennifer 8. (15 April 2003). "E.P.A. Orders Companies to Examine Effects of Chemicals". The New York Times. Retrieved 15 May 2009.
  19. "3M United States: PFOS PFOA: What is 3M Doing?". 3M Company. Archived from the original on 2014-12-10. Retrieved 2009-01-05.
  20. Weber, Joseph (2000-06-05). "3M's Big Cleanup – Why it decided to pull the plug on its best-selling stain repellent". Business Week (3684): 96.
  21. Ward, Jr., Ken (7 November 2008). "DuPont finds high C8 in Chinese workers". The Charleston Gazette. Archived from the original on 2009-02-24. Retrieved 6 January 2009.
  22. Mordock, Jeff (April 1, 2016). "Taking on DuPont: Illnesses, deaths blamed on pollution from W. Va. plant". Delaware Online. Retrieved September 30, 2019.
  23. "GORE completes elimination of PFOA from raw material of its functional fabrics: GORE-TEX Products Newsroom". Gore Fabrics. Retrieved 13 August 2015.
  24. US EPA, OCSPP (2016-05-10). "Fact Sheet: 2010/2015 PFOA Stewardship Program". US EPA. Retrieved 2019-10-21.
  25. Caverly Rae, JM; Craig, Lisa; Stone, Theodore W.; Frame, Steven R.; Buxton, L. William; Kennedy, Gerald L. (2015). "Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague–Dawley rats". Toxicology Reports. 2: 939–949. doi:10.1016/j.toxrep.2015.06.001. PMC 5598527. PMID 28962433.
  26. Arneson, Gerald J. (November 1961). Toxicity of Teflon Dispersing Agents (PDF). DuPont, Polychemicals Department, Research & Development Division, Experimental Station. Archived from the original (PDF) on 2006-10-02. Retrieved 2008-09-21.
  27. Clapp, Richard; Polly Hoppin; Jyotsna Jagai; Sara Donahue. "Case Studies in Science Policy: Perfluorooctanoic Acid". Project on Scientific Knowledge and Public Policy (SKAPP). Archived from the original on 2009-03-01. Retrieved 2008-12-19.
  28. Rebholz, Sandra L.; Jones, Thomas; Herrick, Robert L.; Xie, Changchun; Calafat, Antonia M.; Pinney, Susan M.; Woollett, Laura A. (2016). "Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice". Toxicology Reports. 3: 46–54. doi:10.1016/j.toxrep.2015.11.004. PMC 4770828. PMID 26942110.
  29. "Robert Bilott, The Right Livelihood Award". The Right Livelihood Award. Retrieved 24 January 2018.
  30. "DuPont vs. the World: Chemical Giant Covered Up Health Risks of Teflon Contamination Across Globe". Democracy Now!. Retrieved 24 January 2018.
  31. Savu, Patricia M. (2000). "Fluorinated Higher Carboxylic Acids". Kirk-Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.0612211519012221.a01. ISBN 978-0-471-23896-6.
  32. Goeden, Helen (June 2008). Issues and Needs for PFAA Exposure and Health Research: A State Perspective (PDF). PFAA Days II. Minnesota Department of Health. U.S. EPA – Research Triangle Park. Archived from the original (PDF) on 2011-07-26. Retrieved 2008-12-02.
  33. Lehmler, H. J. (2005). "Synthesis of environmentally relevant fluorinated surfactants—a review". Chemosphere. 58 (11): 1471–1496. Bibcode:2005Chmsp..58.1471L. doi:10.1016/j.chemosphere.2004.11.078. PMID 15694468.
  34. Ylinen M, Hanhijärvi H, Peura P, Rämö O (November 1985). "Quantitative gas chromatographic determination of perfluorooctanoic acid as the benzyl ester in plasma and urine". Arch. Environ. Contam. Toxicol. 14 (6): 713–7. doi:10.1007/BF01055778. PMID 4073944.
  35. "PFOA in Norway TA-2354/2007" (PDF). Norwegian Pollution Control Authority. 2007. p. 6. Retrieved 6 April 2009.
  36. "Information on PFOA". DuPont. Retrieved 23 May 2009.
  37. Siegle, Lucy (11 October 2009). "Do environmentally friendly outdoor jackets exist?". The Observer. London. Retrieved 25 October 2009.
  38. Kudo N, Kawashima Y (May 2003). "Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals". J. Toxicol. Sci. 28 (2): 49–57. doi:10.2131/jts.28.49. PMID 12820537.
  39. Kudo N, Suzuki-Nakajima E, Mitsumoto A, Kawashima Y (September 2006). "Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase". Biol. Pharm. Bull. 29 (9): 1952–7. doi:10.1248/bpb.29.1952. PMID 16946516.
  40. Gordon S. C. (September 2010). "Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing". Regul Toxicol Pharmacol. 59 (1): 64–80. doi:10.1016/j.yrtph.2010.09.008. PMID 20875479.
  41. Sandy, Martha. Petition for Expedited CIC Consideration of Perfluorooctanic Acid (PFOA) (PDF). State of California, Office of Environmental Health Hazard Assessment, Cancer Toxicology and Epidemiology Section, Reproductive and Cancer Hazard Assessment Branch. Retrieved 2008-09-27.
  42. Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (October 2007). "Perfluoroalkyl acids: a review of monitoring and toxicological findings". Toxicol. Sci. 99 (2): 366–94. doi:10.1093/toxsci/kfm128. PMID 17519394.
  43. Michael McCoy (November 2008). "Dyneon Phasing Out Perfluorooctanoate". Chemical & Engineering News. 86 (46): 26. doi:10.1021/cen-v086n033.p026.
  44. "Learn More About DuPont Teflon". DuPont. Retrieved 16 May 2009.
  45. Renner, Rebecca (June 2003). "Concerns over common perfluorinated surfactant". Environ. Sci. Technol. 37 (11): 201A–2A. Bibcode:2003EnST...37..201R. doi:10.1021/es032467q. PMID 12831000.
  46. G. Siegemund; W. Schwertfeger; A. Feiring; B. Smart; F. Behr; H. Vogel; B. McKusick (2005). "Fluorine Compounds, Organic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH.
  47. EPA (7 March 2006). "Premanufacture Notification Exemption for Polymers; Amendment of Polymer Exemption Rule to Exclude Certain Perfluorinated Polymers; Proposed Rule" (PDF). Federal Register. 71 (44): 11490.
  48. Guo Z, Liu X, Krebs KA (March 2009). "Perfluorocarboxylic Acid Content in 116 Articles of Commerce" (PDF). EPA. p. 40.
  49. https://casaweb.org/wp-content/uploads/2020/01/National-PFAS-Receivers-Factsheet.pdf
  50. Betts KS (May 2007). "Perfluoroalkyl acids: what is the evidence telling us?". Environ. Health Perspect. 115 (5): A250–6. doi:10.1289/ehp.115-a250. PMC 1867999. PMID 17520044.
  51. "PFAS Fact Sheet" (PDF). Retrieved 31 March 2020.
  52. Yamashita N, Kannan K, Taniyasu S, Horii Y, Petrick G, Gamo T (2005). "A global survey of perfluorinated acids in oceans". Mar. Pollut. Bull. 51 (8–12): 658–68. doi:10.1016/j.marpolbul.2005.04.026. PMID 15913661.
  53. Renner, Rebecca (June 2008). "Aerosols complicate PFOA picture". Environ. Sci. Technol. 42 (11): 3908. Bibcode:2008EnST...42.3908R. doi:10.1021/es087117o. PMID 18589941.
  54. https://casaweb.org/wp-content/uploads/2020/01/National-PFAS-Receivers-Factsheet.pdf
  55. Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC (June 2006). "Biological monitoring of polyfluoroalkyl substances: A review". Environ. Sci. Technol. 40 (11): 3463–73. Bibcode:2006EnST...40.3463H. doi:10.1021/es052580b. PMID 16786681.
  56. Butt CM, Berger U, Bossi R, Tomy GT (May 2010). "Levels and trends of poly- and perfluorinated compounds in the arctic environment". Sci Total Environ. 408 (15): 2936–65. Bibcode:2010ScTEn.408.2936B. doi:10.1016/j.scitotenv.2010.03.015. PMID 20493516.
  57. Conder JM, Hoke RA, De Wolf W, Russell MH, Buck RC (February 2008). "Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds". Environ. Sci. Technol. 42 (4): 995–1003. Bibcode:2008EnST...42..995C. doi:10.1021/es070895g. PMID 18351063.
  58. Arvaniti O.S., Stasinakis A.S. (2015). "Review on the occurrence, fate and removal of perfluorinated compounds during wastewater treatment". Science of the Total Environment. 524–525: 81–92. Bibcode:2015ScTEn.524...81A. doi:10.1016/j.scitotenv.2015.04.023. PMID 25889547.
  59. Nika M.C., Ntaiou K., Elytis K., Thomaidi V.S., Gatidou G., Kalantzi O.I., Thomaidis N.S., Stasinakis A.S. (2020). "Wide-scope target analysis of emerging contaminants in landfill leachates and risk assessment using RQ methodology". Journal of Hazardous Materials. 394: 122493. doi:10.1016/j.jhazmat.2020.122493.CS1 maint: multiple names: authors list (link)
  60. Vestergren R, Cousins IT (August 2009). "Tracking the pathways of human exposure to perfluorocarboxylates". Environ. Sci. Technol. 43 (15): 5565–75. Bibcode:2009EnST...43.5565V. doi:10.1021/es900228k. PMID 19731646.
  61. Calafat AM, Needham LL, Kuklenyik Z, Reidy JA, Tully JS, Aguilar-Villalobos M, Naeher LP (April 2006). "Perfluorinated chemicals in selected residents of the American continent". Chemosphere. 63 (3): 490–6. Bibcode:2006Chmsp..63..490C. doi:10.1016/j.chemosphere.2005.08.028. PMID 16213555.
  62. Harada KH, Yang HR, Moon CS, Hung NN, Hitomi T, Inoue K, Niisoe T, Watanabe T, Kamiyama S, Takenaka K, Kim MY, Watanabe K, Takasuga T, Koizumi A (April 2010). "Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994–2008 and Vietnam in 2007–2008". Chemosphere. 79 (3): 314–9. Bibcode:2010Chmsp..79..314H. doi:10.1016/j.chemosphere.2010.01.027. PMID 20149408.
  63. Hemat H, Wilhelm M, Völkel W, Mosch C, Fromme H, Wittsiepe J (July 2010). "Low serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) in children and adults from Afghanistan". Sci. Total Environ. 408 (16): 3493–5. Bibcode:2010ScTEn.408.3493H. doi:10.1016/j.scitotenv.2010.04.040. PMID 20471065.
  64. Calafat AM, Wong LY, Kuklenyik Z, Reidy JA, Needham LL (November 2007). "Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999–2000". Environ. Health Perspect. 115 (11): 1596–602. doi:10.1289/ehp.10598. PMC 2072821. PMID 18007991.
  65. Renner, Rebecca (2008). "PFOS phaseout pays off". Environ. Sci. Technol. 42 (13): 4618. Bibcode:2008EnST...42.4618R. doi:10.1021/es0871614. PMID 18677976.
  66. https://casaweb.org/wp-content/uploads/2020/01/National-PFAS-Receivers-Factsheet.pdf
  67. Fuchs, Erin; Sohn, Pam (10 February 2008). "Study finds high levels of stain-resistance ingredient in Conasauga River". Chattanooga Times Free Press. Archived from the original on 6 October 2008. Retrieved 4 October 2008.
  68. Clara M, Scheffknecht C, Scharf S, Weiss S, Gans O (2008). "Emissions of perfluorinated alkylated substances (PFAS) from point sources—identification of relevant branches". Water Sci. Technol. 58 (1): 59–66. doi:10.2166/wst.2008.641. PMID 18653937.
  69. Lin AY, Panchangam SC, Lo CC (April 2009). "The impact of semiconductor, electronics and optoelectronic industries on downstream perfluorinated chemical contamination in Taiwanese rivers". Environ. Pollut. 157 (4): 1365–72. doi:10.1016/j.envpol.2008.11.033. PMID 19117653.
  70. "Substance flow analysis for Switzerland: Perfluorinated surfactants perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA)". The Swiss Federal Office for the Environment (FOEN). 2009. Retrieved 4 November 2010.
  71. Washington JW, Jenkins TM, Rankin K, Naile JE (2015). "Decades-Scale Degradation of Commercial, Side-Chain, Fluorotelomer-based Polymers in Soils & Water". Environ. Sci. Technol. 49 (2): 915–923. Bibcode:2015EnST...49..915W. doi:10.1021/es504347u. PMID 25426868.
  72. Washington JW, Jenkins TM (2015). "Abiotic hydrolysis of fluorotelomer polymers as a source of perfluorocarboxylates at the global scale". Environ. Sci. Technol. 49 (24): 14129–14135. doi:10.1021/acs.est.5b03686. PMID 26526296.
  73. Renner, Rebecca (2007). "PFOA in people". Environ. Sci. Technol. 41 (13): 4497–500. Bibcode:2007EnST...41.4497R. doi:10.1021/es0725697. PMID 17695887.
  74. D'eon JC, Hurley MD, Wallington TJ, Mabury SA (March 2006). "Atmospheric chemistry of N-methyl perfluorobutane sulfonamidoethanol, C4F9SO2N(CH3)CH2CH2OH: kinetics and mechanism of reaction with OH". Environ. Sci. Technol. 40 (6): 1862–8. Bibcode:2006EnST...40.1862D. doi:10.1021/es0520767. PMID 16570609.
  75. Ellis DA, Mabury SA, Martin JW, Muir DC (July 2001). "Thermolysis of fluoropolymers as a potential source of halogenated organic acids in the environment". Nature. 412 (6844): 321–4. Bibcode:2001Natur.412..321E. doi:10.1038/35085548. PMID 11460160.
  76. Ellis DA, Martin JW, Muir DC, Mabury SA (June 2003). "The use of 19F NMR and mass spectrometry for the elucidation of novel fluorinated acids and atmospheric fluoroacid precursors evolved in the thermolysis of fluoropolymers". Analyst. 128 (6): 756–64. Bibcode:2003Ana...128..756E. doi:10.1039/b212658c. PMID 12866900.
  77. Lists of PFOS, PFAS, PFOA, PFCA, related compounds and chemicals that may degrade to PFCA (PDF). Environment Directorate-Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides, and Biotechnology. Organisation for Economic Co-operation and Development. 2007-08-21. Retrieved 2008-09-19.CS1 maint: others (link)
  78. Schultz MM, Higgins CP, Huset CA, Luthy RG, Barofsky DF, Field JA (December 2006). "Fluorochemical mass flows in a municipal wastewater treatment facility". Environ. Sci. Technol. 40 (23): 7350–7. doi:10.1021/es061025m. PMC 2556954. PMID 17180988.
  79. Renner, Rebecca (2008). "Do perfluoropolymers biodegrade into PFOA?". Environ. Sci. Technol. 42 (3): 648–50. Bibcode:2008EnST...42..648R. doi:10.1021/es087093l. PMID 18323078.
  80. Schecter A, Colacino J, Haffner D, Patel K, Opel M, Päpke O, Birnbaum L (2010). "Perfluorinated Compounds, Polychlorinated Biphenyl, and Organochlorine Pesticide Contamination in Composite Food Samples from Dallas, Texas". Environ. Health Perspect. 118 (6): 796–802. doi:10.1289/ehp.0901347. PMC 2898856. PMID 20146964.
  81. "Availability of Draft Toxicological Profile: Perfluoroalkyls". Federal Register. 22 June 2018. Retrieved 22 June 2018.
  82. Langer V, Dreyer A, Ebinghaus R (November 2010). "Polyfluorinated compounds in residential and nonresidential indoor air". Environ. Sci. Technol. 44 (21): 8075–81. Bibcode:2010EnST...44.8075L. doi:10.1021/es102384z. PMID 20925396.
  83. D'eon JC, Mabury SA (2010). "Exploring Indirect Sources of Human Exposure to Perfluoroalkyl Carboxylates (PFCAs): Evaluating Uptake, Elimination and Biotransformation of Polyfluoroalkyl Phosphate Esters (PAPs) in the Rat". Environ Health Perspect. 119 (3): 344–350. doi:10.1289/ehp.1002409. PMC 3059997. PMID 21059488.
  84. Renner R (December 2008). "EPA finds record PFOS, PFOA levels in Alabama grazing fields". Environ. Sci. Technol. 43 (5): 1245–6. doi:10.1021/es803520c. PMID 19350885.
  85. Post, Gloria; Stern, Alan; Murphy, Eileen. "Guidance for PFOA in Drinking Water at Pennsgrove Water Supply Company" (PDF). New Jersey Department of Environmental Protection; Division of Science, Research and Technology. p. 2. Retrieved 7 June 2009.
  86. Johnson, Mark. "Evaluation of Methodologies for Deriving Health-Based Values for PFCs in Drinking Water" (PDF). Agency for Toxic Substances and Disease Registry. pp. 20, 37. Archived from the original (PDF) on 2011-07-26. Retrieved 7 June 2009.
  87. "Information on PFOA". DuPont. Retrieved 14 February 2009.
  88. Renner, Rebecca (January 2006). "It's in the microwave popcorn, not the Teflon pan". Environ. Sci. Technol. 40 (1): 4. Bibcode:2006EnST...40....4R. doi:10.1021/es062599u.
  89. Begley TH, White K, Honigfort P, Twaroski ML, Neches R, Walker RA (October 2005). "Perfluorochemicals: potential sources of and migration from food packaging". Food Addit. Contam. 22 (10): 1023–31. doi:10.1080/02652030500183474. PMID 16227186.
  90. Laufer, Peter (2014). Organic: A Journalist's Quest to Discover the Truth behind Food Labeling. Lyons Press. pp. 142–143. ISBN 978-0-7627-9071-5.
  91. Dan Turner, LinkedIn, retrieved 9/26/15.
  92. Weise, Elizabeth (16 November 2005). "Engineer: DuPont hid facts about paper coating". USA Today. Retrieved 19 September 2008.
  93. "Teflon firm faces fresh lawsuit". BBC News. 19 July 2005. Retrieved 24 January 2009.
  94. "PFOA in Norway TA-2354/2007" (PDF). Norwegian Pollution Control Authority. 2007. p. 18. Retrieved 29 August 2009.
  95. Trudel D, Horowitz L, Wormuth M, Scheringer M, Cousins IT, Hungerbühler K (April 2008). "Estimating consumer exposure to PFOS and PFOA". Risk Anal. 28 (2): 251–69. doi:10.1111/j.1539-6924.2008.01017.x. PMID 18419647.
  96. "Nonstick pans: Nonstick coating risks". Consumer Reports. Retrieved 4 July 2009.
  97. Ward, Jr., Ken (17 January 2009). "EPA's C8 advisory does not address long-term risks". The Charleston Gazette. Archived from the original on 2011-06-24. Retrieved 8 February 2009.
  98. Washington JW, Yoo H, Ellington JJ, Jenkins TM, Libelo EL (2010). "Concentrations, distribution and persistence of perfluoroalkylates in sludge-applied soils near Decatur, Alabama, USA". Environ. Sci. Technol. 44 (22): 8390–8396. Bibcode:2010EnST...44.8390W. doi:10.1021/es1003846. PMID 20949951.
  99. Yoo H, Washington JW, Jenkins TM, Ellington JJ (2011). "Quantitative determination of perfluorochemicals and fluorotelomer alcohols in plants from biosolid-amended fields using LC/MS/MS and GC/MS". Environ. Sci. Technol. 45 (19): 7985–7990. Bibcode:2011EnST...45.7985Y. doi:10.1021/es102972m. PMID 21247105.
  100. Finn, Scott (15 January 2009). "Bush EPA sets so-called safe level of C8 in drinking water". West Virginia Public Broadcasting. Retrieved 18 January 2009.
  101. "Perfluorochemical Contamination of Biosolids Near Decatur, Alabama". EPA. Retrieved 12 June 2010.
  102. Haug, Line S.; Huber, Sandra; Becher, Georg; Thomsen, Cathrine (May 2011). "Characterisation of human exposure pathways to perfluorinated compounds — Comparing exposure estimates with biomarkers of exposure". Environment International. 37 (4): 687–693. doi:10.1016/j.envint.2011.01.011. ISSN 0160-4120. PMID 21334069.
  103. Anderson, Janet K.; Luz, Anthony L.; Goodrum, Philip; Durda, Judi (April 2019). "Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization". Regulatory Toxicology and Pharmacology. 103: 10–20. doi:10.1016/j.yrtph.2019.01.020. ISSN 0273-2300. PMID 30634020.
  104. Washburn, Stephen T.; Bingman, Timothy S.; Braithwaite, Scott K.; Buck, Robert C.; Buxton, L. William; Clewell, Harvey J.; Haroun, Lynne A.; Kester, Janet E.; Rickard, Robert W. (June 2005). "Exposure Assessment and Risk Characterization for Perfluorooctanoate in Selected Consumer Articles". Environmental Science & Technology. 39 (11): 3904–3910. Bibcode:2005EnST...39.3904W. doi:10.1021/es048353b. ISSN 0013-936X. PMID 15984763.
  105. "Drinking Water Health Advisories for PFOA and PFOS". EPA. 2017-08-30.
  106. EPA (2016-05-25). "Lifetime Health Advisories and Health Effects Support Documents for Perfluorooctanoic Acid and Perfluorooctane Sulfonate." Federal Register, 81 FR 33250
  107. EPA (2020-03-10). "Announcement of Preliminary Regulatory Determinations for Contaminants on the Fourth Drinking Water Contaminant Candidate List; Request for public comment." 85 FR 14098
  108. O'Neill, James M. (2017-11-02). "N.J. sets stringent standard on cancer-causing chemical PFOA in drinking water". The Record (Bergen County). Woodland Park, NJ.
  109. "Drinking Water Quality Council Recommends Nation's Most Protective Maximum Contaminant Levels for Three Unregulated Contaminants in Drinking Water". Albany, NY: New York State Department of Health. 2018-12-18. Press release.
  110. Snider, Annie. "White House, EPA headed off chemical pollution study". Politico. Retrieved May 20, 2018.
  111. Benevento, Doug (22 June 2018). "Response to PFAS contamination is coordinated and effective". The Denver Post. Retrieved 22 June 2018.
  112. Agency for Toxic Substances and Disease Registry (ATSDR) (21 June 2018). Toxicological profile for Perfluoroalkyls. (Draft for Public Comment) (PDF). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. p. 34. Retrieved 22 June 2018.
  113. ESFA Panel on Contaminants in the Food Chain (2018). "Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food". EFSA Journal. 16 (12): 5194. doi:10.2903/j.efsa.2018.5194.
  114. "Chemical Used to Make Non-Stick Coatings Harmful to Health". Environment News Service. 13 May 2008. Retrieved 19 October 2008.
  115. Cheryl Hogue (September 2008). "California Chemical Legislation: State's new laws on chemicals could presage federal action". Chemical & Engineering News. 86 (36): 9.
  116. "Calif. law establishes chemical review". San Francisco Chronicle. Associated Press. 29 September 2008. Archived from the original on 9 December 2012. Retrieved 15 February 2009.
  117. Stokstad E (January 2006). "Environmental research—DuPont settlement to fund test of potential toxics". Science. 311 (5757): 26–7. doi:10.1126/science.311.5757.26a. PMID 16400117.
  118. Betts K (November 2007). "PFOS and PFOA in humans: new study links prenatal exposure to lower birth weight". Environ. Health Perspect. 115 (11): A550. doi:10.1289/ehp.115-a550a. PMC 2072861. PMID 18007977.
  119. Hood E (August 2008). "Alternative Mechanism for PFOA?: Trout Studies Shed Light on Liver Effects". Environ. Health Perspect. 116 (8): A351. doi:10.1289/ehp.116-a351b. PMC 2516576.
  120. Upham BL, Park JS, Babica P, Sovadinova I, Rummel AM, Trosko JE, Hirose A, Hasegawa R, Kanno J, Sai K (April 2009). "Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems". Environ. Health Perspect. 117 (4): 545–51. doi:10.1289/ehp.11728. PMC 2679597. PMID 19440492.
  121. "Assessment of PFOA in the drinking water of the German Hochsauerlandkreis" (PDF). Drinking Water Commission (Trinkwasserkommission) of the German Ministry of Health at the Federal Environment Agency. pp. 2–3. Archived from the original (PDF) on 5 November 2010. Retrieved 12 June 2009.
  122. Roos PH, Angerer J, Dieter H, Wilhelm M, Wölfle D, Hengstler JG (January 2008). "Perfluorinated compounds (PFC) hit the headlines: meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology". Arch. Toxicol. 82 (1): 57–9. doi:10.1007/s00204-007-0225-2. PMID 17687546.
  123. Chaparro-Ortega, Andrea; Betancourt, Miguel; Rosas, Patricia; Vázquez-Cuevas, Francisco G.; Chavira, Roberto; Bonilla, Edmundo; Casas, Eduardo; Ducolomb, Yvonne (February 2018). "Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis". Toxicology in Vitro: An International Journal Published in Association with BIBRA. 46: 86–93. doi:10.1016/j.tiv.2017.09.030. ISSN 1879-3177. PMID 28982594.
  124. Cheng J, Psillakis E, Hoffmann MR, Colussi AJ (2009). "Acid Dissociation versus Molecular Association of Perfluoroalkyl Oxoacids: Environmental Implications" (PDF). J. Phys. Chem. A. 113 (29): 8152–6. Bibcode:2009JPCA..113.8152C. doi:10.1021/jp9051352. PMID 19569653.
  125. Cheng X, Klaassen CD (November 2008). "Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors". Toxicol. Sci. 106 (1): 29–36. doi:10.1093/toxsci/kfn147. PMC 2563145. PMID 18648086.
  126. Bartell SM, Calafat AM, Lyu C, Kato K, Ryan PB, Steenland K (February 2010). "Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia". Environ. Health Perspect. 118 (2): 222–8. doi:10.1289/ehp.0901252. PMC 2831921. PMID 20123620.
  127. Steenland K, Fletcher T, Savitz DA (2010). "Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)". Environ. Health Perspect. 118 (8): 1100–8. doi:10.1289/ehp.0901827. PMC 2920088. PMID 20423814.
  128. Brede E, Wilhelm M, Göen T, Müller J, Rauchfuss K, Kraft M, Hölzer J (June 2010). "Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany". Int J Hyg Environ Health. 213 (3): 217–23. doi:10.1016/j.ijheh.2010.03.007. PMID 20488749.
  129. Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010). "Association Between Serum Perfluoroctanoic Acid (PFOA) and Thyroid Disease in the NHANES Study". Environ. Health Perspect. 118 (5): 686–92. doi:10.1289/ehp.0901584. PMC 2866686. PMID 20089479.
  130. Olsen GW, Mair DC, Church TR, et al. (July 2008). "Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000–2006". Environ. Sci. Technol. 42 (13): 4989–95. Bibcode:2008EnST...42.4989O. doi:10.1021/es800071x. PMID 18678038.
  131. Olsen GW, Burris JM, Burlew MM, Mandel JH (November 2000). "Plasma cholecystokinin and hepatic enzymes, cholesterol and lipoproteins in ammonium perfluorooctanoate production workers". Drug Chem. Toxicol. 23 (4): 603–20. doi:10.1081/DCT-100101973. PMID 11071397.
  132. Steenland, Kyle; Susan Woskie (Nov 15, 2012). "Cohort Mortality Study of Workers Exposed to Perfluorooctanoic Acid". American Journal of Epidemiology. 176 (10): 909–17. doi:10.1093/aje/kws171. PMID 23079607.
  133. Fei C, McLaughlin JK, Lipworth L, Olsen J (January 2009). "Maternal levels of perfluorinated chemicals and subfecundity". Hum. Reprod. 24 (5): 1200–1205. doi:10.1093/humrep/den490. PMID 19176540. Archived from the original on 2009-02-01. Retrieved 2009-02-14.
  134. Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebaek NE, Jørgensen N (June 2009). "Do perfluoroalkyl compounds impair human semen quality?". Environ. Health Perspect. 117 (6): 923–7. doi:10.1289/ehp.0800517. PMC 2702407. PMID 19590684.
  135. Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, Chen PC (December 2009). "Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults". Am. J. Gastroenterol. 105 (6): 1354–63. doi:10.1038/ajg.2009.707. PMID 20010922.
  136. Nelson JW, Hatch EE, Webster TF (2009). "Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population" (PDF). Environ. Health Perspect. 118 (2): 197–202. doi:10.1289/ehp.0901165. PMC 2831917. PMID 20123614.
  137. Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM (2010). "Exposure to Polyfluoroalkyl Chemicals and Attention Deficit Hyperactivity Disorder in U.S. Children Aged 12–15 Years". Environ. Health Perspect. 118 (12): 1762–7. doi:10.1289/ehp.1001898. PMC 3002197. PMID 20551004.
  138. Ken Ward Jr. "PFOA linked to ADHD and hormone disruption in kids". Blogs @ The Charleston Gazette. Retrieved 8 November 2009.
  139. Pinney SM, Windham GC, Biro FM, Kushi LH, Yaghjyan L, Calafat A, Kato K, Succop P, Brown MK, Hernick A, Bornschein R (2009). "Perfluorooctanoic acid (PFOA) and Pubertal Maturation in Young Girls". Epidemiology. 20 (6): S80. doi:10.1097/01.ede.0000362949.30847.cb. Retrieved 8 November 2009.
  140. "Patterns of age of puberty among children in the Mid-Ohio Valley in relation to Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS)" (PDF). C8 Science Panel. Retrieved 21 October 2010.
  141. Barry, Vaughn; Winquist, Andrea; Steenland, Kyle (November 2013). "Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant". Environmental Health Perspectives. 121 (11–12): 1313–1318. doi:10.1289/ehp.1306615. ISSN 0091-6765. PMC 3855514. PMID 24007715.
  142. Vested, Anne; Ramlau-Hansen, Cecilia Høst; Olsen, Sjurdur Frodi; Bonde, Jens Peter; Kristensen, Susanne Lund; Halldorsson, Thorhallur Ingi; Becher, Georg; Haug, Line Småstuen; Ernst, Emil Hagen (April 2013). "Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men". Environmental Health Perspectives. 121 (4): 453–458. doi:10.1289/ehp.1205118. ISSN 1552-9924. PMC 3620740. PMID 23360585.
  143. Kristensen, S. L.; Ramlau-Hansen, C. H.; Ernst, E.; Olsen, S. F.; Bonde, J. P.; Vested, A.; Halldorsson, T. I.; Becher, G.; Haug, L. S. (December 2013). "Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction". Human Reproduction (Oxford, England). 28 (12): 3337–3348. doi:10.1093/humrep/det382. ISSN 1460-2350. PMID 24129614.
  144. Kato, Shizue; Itoh, Sachiko; Yuasa, Motoyuki; Baba, Toshiaki; Miyashita, Chihiro; Sasaki, Seiko; Nakajima, Sonomi; Uno, Akiko; Nakazawa, Hiroyuki (September 2016). "Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health". Environmental Health and Preventive Medicine. 21 (5): 334–344. doi:10.1007/s12199-016-0534-2. ISSN 1347-4715. PMC 5305986. PMID 27137816.
  145. Halldorsson, Thorhallur I.; Rytter, Dorte; Haug, Line Småstuen; Bech, Bodil Hammer; Danielsen, Inge; Becher, Georg; Henriksen, Tine Brink; Olsen, Sjurdur F. (May 2012). "Prenatal Exposure to Perfluorooctanoate and Risk of Overweight at 20 Years of Age: A Prospective Cohort Study". Environmental Health Perspectives. 120 (5): 668–673. doi:10.1289/ehp.1104034. ISSN 0091-6765. PMC 3346773. PMID 22306490.
  146. Stein, Cheryl R.; Savitz, David A.; Bellinger, David C. (July 2013). "Perfluorooctanoate and neuropsychological outcomes in children". Epidemiology. 24 (4): 590–599. doi:10.1097/EDE.0b013e3182944432. ISSN 1531-5487. PMC 4020323. PMID 23680941.
  147. Stein, Cheryl R.; Savitz, David A.; Elston, Beth; Thorpe, Phoebe G.; Gilboa, Suzanne M. (August 2014). "Perfluorooctanoate exposure and major birth defects". Reproductive Toxicology. 47: 15–20. doi:10.1016/j.reprotox.2014.04.006. PMC 4117925. PMID 24803403.
  148. Fei C, McLaughlin JK, Tarone RE, Olsen J (November 2007). "Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort". Environ. Health Perspect. 115 (11): 1677–82. doi:10.1289/ehp.10506. PMC 2072850. PMID 18008003.
  149. Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR (November 2007). "Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth". Environ. Health Perspect. 115 (11): 1670–6. doi:10.1289/ehp.10334. PMC 2072847. PMID 18008002.
  150. Andersen CS, Fei C, Gamborg M, Nohr EA, Sørensen TI, Olsen J (October 2010). "Prenatal Exposures to Perfluorinated Chemicals and Anthropometric Measures in Infancy". Am J Epidemiol. 172 (11): 1230–7. doi:10.1093/aje/kwq289. PMID 20940176.
  151. Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R (April 2009). "Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth". Environ. Health Perspect. 117 (4): 660–7. doi:10.1289/ehp.11681. PMC 2679613. PMID 19440508.
  152. Monroy R, Morrison K, Teo K, Atkinson S, Kubwabo C, Stewart B, Foster WG (September 2008). "Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples". Environ. Res. 108 (1): 56–62. Bibcode:2008ER....108...56M. doi:10.1016/j.envres.2008.06.001. PMID 18649879.
  153. Nolan LA, Nolan JM, Shofer FS, Rodway NV, Emmett EA (June 2009). "The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water". Reprod. Toxicol. 27 (3–4): 231–8. doi:10.1016/j.reprotox.2008.11.001. PMC 3039136. PMID 19049861.
  154. Negri, Eva; Metruccio, Francesca; Guercio, Valentina; Tosti, Luca; Benfenati, Emilio; Bonzi, Rossella; La Vecchia, Carlo; Moretto, Angelo (2017-02-15). "Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data". Critical Reviews in Toxicology. 47 (6): 489–515. doi:10.1080/10408444.2016.1271972. ISSN 1040-8444. PMID 28617200.
  155. Eriksen KT, Sørensen M, McLaughlin JK, Lipworth L, Tjønneland A, Overvad K, Raaschou-Nielsen O (April 2009). "Perfluorooctanoate and perfluorooctanesulfonate plasma levels and risk of cancer in the general Danish population". J. Natl. Cancer Inst. 101 (8): 605–9. doi:10.1093/jnci/djp041. PMID 19351918.
  156. Fei C, McLaughlin JK, Lipworth L, Olsen J (November 2010). "Prenatal exposure to PFOA and PFOS and risk of hospitalization for infectious diseases in early childhood". Environ. Res. 110 (8): 773–7. Bibcode:2010ER....110..773F. doi:10.1016/j.envres.2010.08.004. PMID 20800832.
  157. Fei C, Olsen J (2010). "Prenatal Exposure to Perfluorinated Chemicals and Behavioral or Coordination Problems at Age 7". Environ. Health Perspect. 119 (4): 573–578. doi:10.1289/ehp.1002026. PMC 3080943. PMID 21062688.
  158. Fei C, McLaughlin JK, Lipworth L, Olsen J (October 2008). "Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy". Environ. Health Perspect. 116 (10): 1391–5. doi:10.1289/ehp.11277. PMC 2569100. PMID 18941583.
  159. C8 Science Panel
  160. Steenland K, Tinker S, Frisbee S, Ducatman A, Vaccarino V (November 2009). "Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant". Am. J. Epidemiol. 170 (10): 1268–78. doi:10.1093/aje/kwp279. PMID 19846564.
  161. Frisbee SJ, Brooks AP, Maher A, Flensborg P, Arnold S, Fletcher T, Steenland K, Shankar A, Knox SS, Pollard C, Halverson JA, Vieira VM, Jin C, Leyden KM, Ducatman AM (December 2009). "The C8 health project: design, methods, and participants". Environ. Health Perspect. 117 (12): 1873–82. doi:10.1289/ehp.0800379. PMC 2799461. PMID 20049206.
  162. "Timeline". C8 Science Panel. Archived from the original on 2011-06-04. Retrieved 9 June 2011.
  163. "C8 Science Panel Website". C8sciencepanel.org. Retrieved 2016-01-09.
  164. Cortese, Amy (8 August 2004). "DuPont, Now in the Frying Pan". The New York Times. p. 3. Retrieved 30 December 2008.
  165. Summers, Chris (7 October 2004). "Teflon's sticky situation". BBC News. Retrieved 30 December 2008.
  166. "Biomonitoring—EPA Needs to Coordinate Its Research Strategy and Clarify Its Authority to Obtain Biomonitoring Data" (PDF). United States Government Accountability Office. April 2009. pp. 19–20. Retrieved 19 June 2009.
  167. "Relationship of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with pregnancy outcome among women with elevated community exposure to PFOA" (PDF). C8 Science Panel. Retrieved 27 June 2009.
  168. "C8 Science Panel Website – C8 Study Results – Status Reports". C8 Science Panel. Archived from the original on 2008-11-21. Retrieved 27 June 2009.
  169. Chemicals proposed for listing under the Convention
  170. "Governments agree landmark decisions to protect people and planet from hazardous chemicals and waste, including plastic waste". BRSMeas. Retrieved 2019-05-14.
  171. Ken Ward, Jr. (28 September 2009). "Federal judge throws out most of C8 suit against DuPont". The Charleston Gazette.
  172. , et al. v. E.I. Du Pont De Nemours and Company Settlement ans Lubeck Public Service District at the Wayback Machine (archived September 19, 2010)
  173. Janofsky, Michael (2005-12-15). "DuPont to Pay $16.5 Million for Unreported Risks". The New York Times.
  174. Goodwin, C.J. "Rhodes, et al. v. E.I. Du Pont De Nemours and Company" Archived 2010-05-27 at the Wayback Machine United States District Court for the Southern District of West Virginia. Case Number, 6:06-cv-530 (30 September 2008). Retrieved 12 October 2008.
  175. Archived May 27, 2010, at the Wayback Machine
  176. Gensler, Lauren. "DuPont Puts Toxic Exposure Lawsuits Behind It With $671 Million Settlement". Forbes. Retrieved 2019-11-19.
  177. "2010/15 PFOA Stewardship Program; PFOA and Fluorinated Telomers". EPA. Archived from the original on 27 October 2008. Retrieved 19 September 2008.
  178. Renner R; Christen, Kris (2006). "Scientists hail PFOA reduction plan". Environ. Sci. Technol. 40 (7): 2075–6. doi:10.1021/es062654z. PMID 16646434.
  179. SAB Review of EPA's Draft Risk Assessment of Potential Human Health Effects Associated with PFOA and Its Salts (PDF). EPA Science Advisory Board. 2006-05-30. p. 2. Retrieved 2008-09-21.
  180. Mid-Atlantic Enforcement (10 May 2007). "Fact Sheet: EPA, DuPont Agree on Measures to Protect Drinking Water Near the DuPont Washington Works". EPA. Archived from the original on 18 January 2008. Retrieved 11 May 2008.
  181. "Drinking Water Health Advisories for PFOA and PFOS". EPA. 19 May 2016. Retrieved 23 May 2016.
  182. Renner, Rebecca; Cooney, Catherine M.; Pelley, Janet; Chatterjee, Rhitu; Lubick, Naomi; Engelhaupt, Erika (May 2007). "New Jersey dives into PFOA water guidance". Environ. Sci. Technol. 41 (10): 3395–6. doi:10.1021/es072532m. PMID 17547148.
  183. "Health officials issue new health guidelines for PFOA, PFOS". Minnesota Department of Health. 2007-03-01. News Release. Archived from the original on 2007-08-14.
  184. "Secretariats of the Basel, Rotterdam and Stockholm Conventions (BRS Conventions)". 2016-11-02. doi:10.1787/9789264244047-16-en. Missing or empty |url= (help)
  185. Anke Schaefer; Barbara Booth; Naomi Lubick; Kellyn S. Betts (2006-12-01). "Perfluorinated surfactants contaminate German waters—Mislabeled waste in fertilizer leads to a water scandal". Environ. Sci. Technol. 40 (23): 7108–14. doi:10.1021/es062811u.
  186. Skutlarek D, Exner M, Färber H (September 2006). "Perfluorinated surfactants in surface and drinking waters". Environ. Sci. Pollut. Res. Int. 13 (5): 299–307. doi:10.1065/espr2006.07.326. PMID 17067024. Archived from the original on 2008-09-05. Retrieved 2008-10-04.
  187. "Risicoschatting emissie PFOA voor omwonenden : Locatie: DuPont/Chemours, Dordrecht, Nederland". rivm.nl. Retrieved 2016-08-31.
  188. Official Journal of the European Union, L 150, 14 June 2017.
  189. Gayner, Oliver (2016-08-10). "Press Release: Williamtown Contamination Class Action". LinkedIn. IMF Bentham. Retrieved 2016-08-22.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.