Neoabietadiene synthase

Neoabietadiene synthase (EC 4.2.3.132, AgAS, PtTPS-LAS) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming).[1][2][3] This enzyme catalyses the following chemical reaction:

(+)-copalyl diphosphate neoabietadiene + diphosphate
Neoabietadiene synthase
Identifiers
EC number4.2.3.132
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from Abies grandis (grand fir).

References

  1. Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau RB (2000). "Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme". Biochemistry. 39: 15592–15602. doi:10.1021/bi001997l. PMID 11112547.
  2. Zhou K, Gao Y, Hoy JA, Mann FM, Honzatko RB, Peters RJ (February 2012). "Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis". The Journal of Biological Chemistry. 287 (9): 6840–50. doi:10.1074/jbc.M111.337592. PMC 3307272. PMID 22219188.
  3. Ro DK, Bohlmann J (August 2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–8. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
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