Mucin 5AC

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[5][6][7]

MUC5AC
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDsOMIM: 158373 MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start1,157,953 bp[1]
End1,201,138 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4586

17833

Ensembl

ENSG00000215182
ENSG00000283158

ENSMUSG00000037974

UniProt

P98088

n/a

RefSeq (mRNA)

NM_017511
NM_001304359

NM_010844

RefSeq (protein)

NP_001291288

n/a

Location (UCSC)Chr 11: 1.16 – 1.2 MbChr 7: 141.79 – 141.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[8]

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References

  1. ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037974 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
  6. van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
  7. "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
  8. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med. Genom. 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC


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