Mucin 5AC

MUC5AC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373 MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	1,201,138 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	141,819,231 bp[2]
Gene ontology
Molecular function	• extracellular matrix structural constituent;
Cellular component	• cytoplasm; • Golgi lumen; • extracellular region; • extracellular exosome; • extracellular; • cell membrane; • mucus layer;
Biological process	• phosphatidylinositol-mediated signaling; • O-glycan processing; • stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4586
	17833
	ENSG00000215182; ENSG00000283158
	ENSMUSG00000037974
	P98088
	n/a
	NM_017511; NM_001304359
	NM_010844
	NP_001291288
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[5][6][7]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[8]

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ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037974 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
"Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med. Genom. 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.

PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC

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