Miltiradiene synthase
Miltiradiene synthase (EC 4.2.3.131, SmMDS, SmiKSL) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming).[1][2] This enzyme catalyses the following chemical reaction
- (+)-copalyl diphosphate miltiradiene + diphosphate
| Miltiradiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.131 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is isolated from the plant Selaginella moellendorffii.
References
- Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, Yang B, Peters RJ (November 2009). "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights". Organic Letters. 11 (22): 5170–3. doi:10.1021/ol902051v. PMC 2776380. PMID 19905026.
- Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, Natsume M, Nozaki H, Kawaide H (December 2011). "Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii". The Journal of Biological Chemistry. 286 (50): 42840–7. doi:10.1074/jbc.m111.302703. PMC 3234827. PMID 22027823.
External links
- Miltiradiene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.