Melanoma-associated antigen

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1i4fC:230-239 1qewC:271-279

MAGE family
Identifiers
Symbol	MAGE
Pfam	PF01454
InterPro	IPR002190
SCOPe	1i4f / SUPFAM
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1i4fC:230-239 1qewC:271-279

The mammalian members of the MAGE (melanoma-associated antigen) gene family were originally described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. By contrast, these genes were expressed in various kinds of tumors.

MAGE-like genes have also been identified in non-mammalian species, like the zebrafish or Drosophila melanogaster. Although no MAGE homologous sequences have been identified in Caenorhabditis elegans, Saccharomyces cerevisiae or Schizosaccharomyces pombe, MAGE sequences have been found in several vegetal species, including Arabidopsis thaliana.[1]

The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminus, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. It has been proposed that the MAGE conserved domain of MAGE-D proteins might interact with p75 neurotrophin or related receptors.[1]

Human proteins containing this domain

MAGE-B1; MAGEA1; MAGEA10; MAGEA11; MAGEA12; MAGEA2B; MAGEA3; MAGEA4; MAGEA6; MAGEA8; MAGEA9; MAGEB1; MAGEB10; MAGEB16; MAGEB18; MAGEB2; MAGEB3; MAGEB4; MAGEB5; MAGEB6; MAGEB6B; MAGEC1; MAGEC2; MAGEC3; MAGED1; MAGED2; MAGED4; MAGEE1; MAGEE2; MAGEF1; MAGEH1; MAGEL2; NDN; NDNL2;

gollark: There are some microwaves which generate 2.4GHz using something something transistors. But it's MORE expensive than magnetrons.

gollark: <:Transistor:694654534634569809> <:Transistor:694654534634569809>

gollark: I see.

gollark: What does the QCW stand for?

gollark: Sometimes you just want to cool down and possibly remove a large chunk of wall or something.

References

Chomez P, Bertrand M, Boon T, Lucas S, De Backer O, De Plaen E (2001). "An overview of the MAGE gene family with the identification of all human members of the family". Cancer Res. 61 (14): 5544–5551. PMID 11454705.

This article incorporates text from the public domain Pfam and InterPro: IPR002190

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[PUB00007179-1] Chomez P, Bertrand M, Boon T, Lucas S, De Backer O, De Plaen E (2001). "An overview of the MAGE gene family with the identification of all human members of the family". Cancer Res. 61 (14): 5544–5551. PMID 11454705.