MAGEB2

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.[5][6]

MAGEB2
Identifiers
Aliases	MAGEB2, CT3.2, DAM6, MAGE-XP-2, MAGE family member B2
External IDs	OMIM: 300098 MGI: 2148568 HomoloGene: 134515 GeneCards: MAGEB2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp21.2 Start 30,215,563 bp[1] End 30,220,089 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C1 Start 86,250,254 bp[2] End 86,305,093 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4113	434903
Ensembl	ENSG00000099399	ENSMUSG00000035427
UniProt	O15479	A2A9R3
RefSeq (mRNA)	NM_002364	NM_001033492
RefSeq (protein)	NP_002355	NP_001028664
Location (UCSC)	Chr X: 30.22 – 30.22 Mb	Chr X: 86.25 – 86.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000099399 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lurquin C, De Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, Brasseur R, Monaco AP, Boon T (Mar 1998). "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins". Genomics. 46 (3): 397–408. doi:10.1006/geno.1997.5052. PMID 9441743.
6. "Entrez Gene: MAGEB2 melanoma antigen family B, 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Dabovic B, Zanaria E, Bardoni B, et al. (1996). "A family of rapidly evolving genes from the sex reversal critical region in Xp21". Mamm. Genome. 6 (9): 571–80. doi:10.1007/BF00352360. PMID 8535061.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• McCurdy DK, Tai LQ, Nguyen J, et al. (1998). "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera". Mol. Genet. Metab. 63 (1): 3–13. doi:10.1006/mgme.1997.2639. PMID 9538511.
• Lee JH, Sung BW, Youn HJ, Park JH (2001). "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen". Mol. Cells. 10 (6): 647–53. doi:10.1007/s10059-000-0647-7. PMID 11211869.
• Park JH, Lee SW (2003). "Hypertonicity induction of melanoma antigen, a tumor-associated antigen". Mol. Cells. 13 (2): 288–95. PMID 12018852.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Milutinovic S, D'Alessio AC, Detich N, Szyf M (2007). "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes". Carcinogenesis. 28 (3): 560–71. doi:10.1093/carcin/bgl167. PMID 17012225.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.